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Dolutegravir Impurity C

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Dolutegravir Impurity C Basic information

Product Name:
Dolutegravir Impurity C
Synonyms:
  • Dolutegravir Impurity 20
  • (4R,12aS)-N-(2,4-difluorobenzyl)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1,2:
  • Dolutegravir Impurity 23
  • (4R,12aS)-N-(2,4-difluorobenzyl)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-7-ethoxy-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-, (4R,12aS)-
  • Dolutegravir Impurity 32
  • Syringaresinol Impurity 1(Syringaresinol Diglucoside)
  • Durutevir impurity 23
CAS:
1802141-49-6
MF:
C22H23F2N3O5
MW:
447.43
Mol File:
1802141-49-6.mol
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Dolutegravir Impurity C Chemical Properties

Boiling point:
688.1±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
pka
10.71±0.40(Predicted)
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Dolutegravir Impurity C Usage And Synthesis

Uses

O-Ethyl Dolutegravir is an impurity of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

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