ChemicalBook > CAS DataBase List > JX401

JX401

Product Name
JX401
CAS No.
349087-34-9
Chemical Name
JX401
Synonyms
JX401;p38 MAP Kinase Inhibitor VI, JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
CBNumber
CB01074327
Molecular Formula
C21H25NO2S
Formula Weight
355.49
MOL File
349087-34-9.mol
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JX401 Property

storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form 
Off-white solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9/PG 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
506157
Product name
p38 MAP Kinase Inhibitor VI, JX401
Packaging
5mg
Price
$251
Updated
2023/06/20
Cayman Chemical
Product number
16898
Product name
JX-401
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
16898
Product name
JX-401
Purity
≥95%
Packaging
5mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
16898
Product name
JX-401
Purity
≥95%
Packaging
10mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
16898
Product name
JX-401
Purity
≥95%
Packaging
50mg
Price
$820
Updated
2024/03/01
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JX401 Chemical Properties,Usage,Production

Description

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.

Uses

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]

Uses

JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.

Definition

ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

storage

Room temperature

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

JX401 Preparation Products And Raw materials

Raw materials

Preparation Products

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JX401 Suppliers

China 46 Germany 1 Switzerland 1 United Kingdom 1 United States 10 USA 1 Global 60
3B Pharmachem (Wuhan) International Co.,Ltd.
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349087-34-9, JX401Related Search:

CHK2 INHIBITOR II SC-514 BML-259 GW5074 Pifithrin-α (PFTα) SB 220025 PRIMA-1 PD 169316 FHPI HCL CP 31398 SB 239063 SB 202190 CYCLIC-PIFITHRIN-ALPHA 1H-INDOLE-5-CARBOXAMIDE, 97% JX401 (2-HYDROXY-PHENYL)-PIPERIDIN-1-YL-METHANONE

  • JX401
  • 1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
  • 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
  • p38 MAP Kinase Inhibitor VI, JX401
  • p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem
  • Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
  • 349087-34-9
  • Intracellular Signaling