JX401
- Product Name
- JX401
- CAS No.
- 349087-34-9
- Chemical Name
- JX401
- Synonyms
- JX401;p38 MAP Kinase Inhibitor VI, JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
- CBNumber
- CB01074327
- Molecular Formula
- C21H25NO2S
- Formula Weight
- 355.49
- MOL File
- 349087-34-9.mol
JX401 Property
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
- form
- Off-white solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 506157
- Product name
- p38 MAP Kinase Inhibitor VI, JX401
- Packaging
- 5mg
- Price
- $251
- Updated
- 2023/06/20
- Product number
- 16898
- Product name
- JX-401
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 16898
- Product name
- JX-401
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 16898
- Product name
- JX-401
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 16898
- Product name
- JX-401
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $820
- Updated
- 2024/03/01
JX401 Chemical Properties,Usage,Production
Description
JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.
Uses
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]
Uses
JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.
Definition
ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
Biological Activity
Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
storage
Room temperature
References
1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.