5-Bromo-2-iodopyridine

Product Name: 5-Bromo-2-iodopyridine
CAS No.: 223463-13-6
Chemical Name: 5-Bromo-2-iodopyridine
Synonyms: 2-IODO-5-BROMOPYRIDINE;CAS:223463-13-6;5-Brom-2-iodpyridin;5-bromo-2-lodopyridine;5-BROMO-2-IDIOPYRIDINE;5-BROMO-2-IODOPYRIDINE;5-CroMo-2-iodopyridine;2-iodine-5-broMopyridine;PYRIDINE, 5-BROMO-2-IODO-;5-Bromo-2-Iodopyridine99%
CBNumber: CB0111175
Molecular Formula: C5H3BrIN
Formula Weight: 283.89
MOL File: 223463-13-6.mol

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5-Bromo-2-iodopyridine Property

Melting point:: 113-117 °C (lit.)
Boiling point:: 258.8±20.0 °C(Predicted)
Density: 2.347±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol (Slightly)
pka: -0.51±0.10(Predicted)
form: Crystalline Powder
color: White to beige
Sensitive: Light Sensitive
BRN: 2119
Stability:: Light Sensitive
InChI: InChI=1S/C5H3BrIN/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey: HSNBRDZXJMPDGH-UHFFFAOYSA-N
SMILES: C1(I)=NC=C(Br)C=C1
CAS DataBase Reference: 223463-13-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, LIGHT SENSITIVE
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 569607
Product name: 5-Bromo-2-iodopyridine
Purity: 97%
Packaging: 5g
Price: $44.52
Updated: 2025/07/31

Sigma-Aldrich

Product number: 569607
Product name: 5-Bromo-2-iodopyridine
Purity: 97%
Packaging: 25g
Price: $80.5
Updated: 2025/07/31

TCI Chemical

Product number: B2877
Product name: 5-Bromo-2-iodopyridine
Purity: >97.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B2877
Product name: 5-Bromo-2-iodopyridine
Purity: >97.0%(GC)
Packaging: 25g
Price: $186
Updated: 2025/07/31

TRC

Product number: B687630
Product name: 5-Bromo-2-iodopyridine
Packaging: 10g
Price: $65
Updated: 2021/12/16

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5-Bromo-2-iodopyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

5-Bromo-2-iodopyridine may be used in the synthesis of the following:

5-bromopyridyl-2-magnesium chloride via reaction with isopropylmagnesium chloride solution
5-bromo-2-pyridylzinc iodide via treatment with active zinc in tetrahydrofuran
5-bromo-2-(trifluoromethyl)pyridine via halogen/trifluoromethyl displacement reaction
(5-bromopyridin-2-yl)zinc(II) chloride via multi-step synthesis
5,5′-dibromo-2,2′-bipyridine via multi-step synthesis

Synthesis

624-28-2

223463-13-6

The general procedure for the synthesis of 5-bromo-2-iodopyridine from 2,5-dibromopyridine was as follows: an aqueous solution of 57% hydriodic acid (HI) was added to a reaction system containing 2,5-dibromopyridine (12.60 g, 53.2 mmol) and sodium iodide (NaI, 11.40 g, 76 mmol). The reaction mixture was heated to reflux for 24 h, subsequently cooled to room temperature and diluted with 100 mL of water. The pH of the mixture was adjusted to alkaline with sodium bicarbonate (NaHCO3), and then treated with the addition of sodium dithionite (Na2S2O4) until the solution became colorless. The reaction mixture was extracted with dichloromethane (DCM, 5 x 60 mL), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the obtained residue was collected by filtration, washed with ether (Et2O, 60 mL) and dried over air to give 5-bromo-2-iodopyridine (8.28 g, 55% yield) as a light gray powder.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 17, p. 4528 - 4532
[2] Chemical Communications, 2012, vol. 48, # 8, p. 1120 - 1122
[3] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[4] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 605 - 608
[5] Organic Letters, 2004, vol. 6, # 26, p. 4905 - 4907

5-Bromo-2-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE

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5-Bromo-2-iodopyridine Suppliers

Americas 1 Belgium 1 China 349 Europe 3 France 1 Germany 6 India 22 Japan 2 Jordan 1 Poland 1 Switzerland 2 Ukraine 1 United Kingdom 13 United States 49 Global 452

XPERTICK (SHANDONG) BIO-PHARMACEUTICAL CO., LTD

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View Lastest Price from 5-Bromo-2-iodopyridine manufacturers

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: 5-Bromo-2-iodopyridine 223463-13-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2025-08-21

Hebei Fengjia New Material Co., Ltd

Product: 5-Bromo-2-iodopyridine 223463-13-6
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Bromo-2-iodopyridine 223463-13-6
Price: US $8.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

223463-13-6, 5-Bromo-2-iodopyridineRelated Search:

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5-BROMO-2-IODOPYRIDINE 97%

5-bromo-2-iodopyridine 97% 5g

5-Bromo-2-iodopyridine, 98+%

5-BROMO-2-IDIOPYRIDINE

5-bromo-2-lodopyridine

2-iodine-5-broMopyridine

5-CroMo-2-iodopyridine

PYRIDINE, 5-BROMO-2-IODO-

5-BROMO-2-IODOPYRIDINE

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5-Bromo-2-Iodopyridine99%

JR-6788, 5-Bromo-2-iodopyridine, 97%

5-Bromo-2-iodopyridine &gt

5-Bromo-2-iodopyridine ISO 9001：2015 REACH

5-Brom-2-iodpyridin

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CAS:223463-13-6

223463-13-6

C5H3BrIN

C5H3NBrI

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines derivates

Heterocycle

Bromopyridines

Halopyridines

Iodopyridines

Heterocycles

alkyl Iodine|alkyl Iodine

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

blocks

Bromides

Iodides

Pyridines

Pyridine

pyridine derivative

Pyridine Series

Halides