NPS 2143
- Product Name
- NPS 2143
- CAS No.
- 284035-33-2
- Chemical Name
- NPS 2143
- Synonyms
- CS-276;CS-1600;NPS 2143;SB262470;SB 262470A;NPS-2143 base;NPS-2143 NPS2143;NPS 2143 USP/EP/BP;SB-262470(NPS-2143);NPS-2143 (SB-262470)
- CBNumber
- CB01512638
- Molecular Formula
- C24H25ClN2O2
- Formula Weight
- 408.92
- MOL File
- 284035-33-2.mol
NPS 2143 Property
- Boiling point:
- 608.4±55.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
- form
- Powder
- pka
- 13.67±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3626
- Product name
- NPS2143 hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $908
- Updated
- 2021/12/16
- Product number
- 256031
- Product name
- NPS 2143 hydrochloride
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- HCH0029514
- Product name
- 2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.71
- Updated
- 2021/12/16
- Product number
- orb181069
- Product name
- NPS-2143(SB 262470A )
- Purity
- >98%
- Packaging
- 100mg
- Price
- $578
- Updated
- 2021/12/16
- Product number
- CS-0319
- Product name
- NPS-2143
- Purity
- 99.34%
- Packaging
- 100mg
- Price
- $660
- Updated
- 2021/12/16
NPS 2143 Chemical Properties,Usage,Production
Uses
NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.
Biological Activity
nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..
target
Ca(2+) receptor
References
[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.
NPS 2143 Preparation Products And Raw materials
Raw materials
Preparation Products
NPS 2143 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from NPS 2143 manufacturers
- Product
- NPS 2143 284035-33-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25