ChemicalBook > CAS DataBase List > BOC-L-4-Nitrophe

BOC-L-4-Nitrophe

Product Name: BOC-L-4-Nitrophe
CAS No.: 33305-77-0
Chemical Name: BOC-L-4-Nitrophe
Synonyms: Phe(4-NO2);D-Phe.otBu.HCl;BOC-L-4-NITROPHE;BOC-L-PHE(4-NO2);Boc-4-NO2-Phe-OH;BOC-PHE(4''-NO2);BOC-(P-NO2)PHE-OH;BOC-PNO2-L-PHE-OH;BOC-PHE(4-NO2)-OH;BOC-PHE(P-NO2)-OH
CBNumber: CB0178783
Molecular Formula: C14H18N2O6
Formula Weight: 310.3
MOL File: 33305-77-0.mol

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BOC-L-4-Nitrophe Property

Melting point:: 107°C
alpha: 8 º (c=1,MeOH)
Boiling point:: 509.3±45.0 °C(Predicted)
Density: 1.290±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethanol (Slightly)
form: Solid
pka: 3.70±0.10(Predicted)
color: Pale Beige
optical activity: [α]20/D +8±1°, c = 1% in methanol
BRN: 2820671
InChI: InChI=1S/C14H18N2O6/c1-14(2,3)22-13(19)15-11(12(17)18)8-9-4-6-10(7-5-9)16(20)21/h4-7,11H,8H2,1-3H3,(H,15,19)(H,17,18)/t11-/m0/s1
InChIKey: XBQADBXCNQPHHY-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 33305-77-0

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15348
Product name: Boc-Phe(4-NO2)-OH
Purity: ≥99.0% (T)
Packaging: 1g
Price: $42.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 15348
Product name: Boc-Phe(4-NO2)-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $109
Updated: 2023/06/20

TCI Chemical

Product number: B2232
Product name: N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine
Purity: >98.0%(T)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: B2232
Product name: N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine
Purity: >98.0%(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TRC

Product number: B658040
Product name: N-Boc-p-nitro-L-phenylalanine
Packaging: 5g
Price: $95
Updated: 2021/12/16

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BOC-L-4-Nitrophe Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

N-Boc-p-nitro-L-phenylalanine is the N-Boc protected form of p-Nitro-L-phenylalanine (N502725, Hydrate) and is a useful synthetic intermediate in the synthesis of Hydroxymelphalan (H939850); an analog of Melphalan (M216900) which is an antineoplastic.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

949-99-5

33305-77-0

To a stirred solution of 4.0 g of (S)-2-amino-3-(4-nitrophenyl)propanoic acid (0.019 mol) in 30 cm3 tert-butanol and 0.8 g of NaOH (0.0209 mol, dissolved in 5 cm3 of water) was added slowly and dropwise at 0 °C 5 cm3 of di-tert-butyl dicarbonate (0.0228 mol, dissolved in 5 cm3 of tert-butanol). The reaction mixture was stirred for 10 h at room temperature. After completion of the reaction (confirmed by thin layer chromatography), the solvent was removed by evaporation and the residue was poured into water and extracted with ethyl acetate (2 x 50 cm3). The organic phases were combined, washed sequentially with 50 cm3 10% citric acid solution and 50 cm3 saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propionic acid as a white solid. Yield: 5.0 g (86% yield); Melting point: 105-106°C (literature value 105-107°C).

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 5, p. 1872 - 1874
[2] Journal of Organic Chemistry, 1999, vol. 64, # 10, p. 3467 - 3475
[3] Patent: US2002/35137, 2002, A1
[4] Monatshefte fur Chemie, 2016, vol. 147, # 11, p. 2001 - 2008
[5] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 638 - 643

BOC-L-4-Nitrophe Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-L-4-Nitrophe manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-4-NO2-Phe-OH 33305-77-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-L-4-Nitrophe 33305-77-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine 33305-77-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

33305-77-0, BOC-L-4-Nitrophe Related Search:

EC 2.6.1.2 4-Nitro-3-phenyl-L-alanine DL-Phenylalanine 4-Nitrobenzoic acid D-Phenylalanine tert-Butanol N-(tert-Butoxycarbonyl)-L-phenylalanine 3-(4-Nitrophenyl)-beta-alanine Boc-Aib-OH D-Alanine N-Carbobenzyloxyglycine Phenprobamate BOC-4-NITRO-D-PHENYLALANINE,BOC-P-NITRO-D-PHENYLALANINE,N-ALPHA-T-BOC-4-NITRO-D-PHENYLALANINE,BOC-D-4-NITROPHE BOC-PHE(3-I)-OH L-Phenylalanine BOC-GLY-LEU-OH BOC-4-Methyl-D-phenylalanine Boc-4-Amino-L-phenylalanine

BOC-PNO2-L-PHE-OH

BOC-(P-NO2)PHE-OH

BOC-P-NITRO-PHENYLALANINE

BOC-P-NITRO-PHE-OH

BOC-PHE(P-NO2)-OH

BOC-PHE(4-NO2)-OH

BOC-L-4-NITROPHE

BOC-L-4-NITROPHENYLALANINE

BOC-L-PHE(4-NO2)

BOC-L-PHE(4-NO2)-OH

BOC-4-NITRO PHENYLALANINE

BOC-4-NITRO-PHE-OH

BOC-4-NITRO-L-PHENYLALANINE

N-(tert-Butyloxycarbonyl)-4-nitro-L-phenylalanine

Boc-L-4-NO2-Phe-OH Boc-4-Nitro-L-Phenylalanine

N-Boc-4-nitro-L-phenylalanine Boc-Phe(4-NO2)-OH

(S)-2-t-butyloxycarbonylaMino-3-(4-nitrophenyl)propionic acid

H-Phe(4'-NO2)-OBut·HCl

Boc-D-4-Nitro-Phe-OH

Boc-4-NO2-Phe-OH

(Tert-Butoxy)Carbonyl Phe(4-NO2)-OH

Phe(4-NO2)

D-Phe.otBu.HCl

L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-4-nitro-

(S)-Boc-2-amino-3-(4-nitrophenyl)propionic acid

Boc-4-nitro-L-phenylalanine≥ 99% (HPLC)

Boc-p-nitro-L-Phe-OH

(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID

RARECHEM BK PT 0074

N-TERT-BUTOXYCARBONYL-4-NITRO-L-PHENYLALANINE

N-TBOC-P-NITRO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-(4-NITROPHENYL)-L-ALANINE

N-ALPHA-T-BOC-4-NITRO-L-PHENYLALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-P-NITRO-L-PHENYLALANINE

N-BOC-4-NITRO-L-PHENYLALANINE

Boc-Phe(4-NO<sub>2</sub>)-OH

N-(tert-butoxycarbonyl)-4-nitro-3-phenyl-L-alanine

N-T-BOC-P-NITRO-L-PHENYLALANINE*FREE ACI D

4-Nitro-L-phenylalanine, N-BOC protected

N-ALPHA-T-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE

Boc-L-4-NO2-Phe-OH

NALPHA-tert-Butoxycarbonyl-3-(4-nitrophenyl)-L-alanine

tert-Butoxycarbonyl-L-4-nitrophenylalanine

BOC-PHE(4''-NO2)

N-TERT-BOC-P-NITRO-L-PHENYLALANINE

N-Boc-p-nitro-L-phenylalanine

N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine&gt

BOC-L-4-Nitrophe USP/EP/BP

Boc-4-nitro-l-phenylalanine, 98%+

BOC-4-Nitro-L-Phenylalanine extrapure, 98%

N-Boc-4-nitro-L-phenylalanine, 95%,

BOC-4-NITRO-L-PHENYLALANINE 98%

(S)-2-(N-BOC-Amino)-3-(4-nitrophenyl)-propanoic acid

33305-77-0

Peptide Synthesis

Phenylalanine Derivatives

Specialty Synthesis