5-CHLORO-3-CYANOPYRIDINE
- Product Name
- 5-CHLORO-3-CYANOPYRIDINE
- CAS No.
- 51269-82-0
- Chemical Name
- 5-CHLORO-3-CYANOPYRIDINE
- Synonyms
- 5-CHLORONICOTINITRILE;5-Chloronicotinontrile;5-CHLORONICOTINONITRILE;3-Chloro-5-cyanopyridine;5-CHLORO-3-CYANOPYRIDINE;PYRIDINE DERIVATIVE 51269-82-0;5-chloro-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-chloro-;5-CHLORO-3-CYANOPYRIDINE ISO 9001：2015 REACH;6-Chloronicotinonitrile 2-Chloro-5-cyanopyridine
- CBNumber
- CB0246774
- Molecular Formula
- C6H3ClN2
- Formula Weight
- 138.55
- MOL File
- 51269-82-0.mol
5-CHLORO-3-CYANOPYRIDINE Property
- Boiling point:
- 208.3±20.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.50±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C380533
- Product name
- 5-Chloronicotinonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C380533
- Product name
- 5-Chloronicotinonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 021382
- Product name
- 5-Chloro-3-cyanopyridine
- Purity
- 96%
- Packaging
- 5g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 021382
- Product name
- 5-Chloro-3-cyanopyridine
- Purity
- 96%
- Packaging
- 25g
- Price
- $563
- Updated
- 2021/12/16
- Product number
- HCH0029744
- Product name
- 3-PYRIDINECARBONITRILE, 2-CHLORO-4,6-DIMETHYL-
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $634.1
- Updated
- 2021/12/16
5-CHLORO-3-CYANOPYRIDINE Chemical Properties,Usage,Production
Uses
5-Chloro-3-cyanopyridine can be used as a building block in the synthesis of other organic compounds.
Synthesis
2457-47-8
544-92-3
51269-82-0
The general procedure for the synthesis of 5-chloro-3-cyanomethylpyridine from 3,5-dichloropyridine and cuprous cyanide was as follows: 3,5-dichloropyridine (4.23 g, 28.6 mmol), cuprous cyanide (CuCN, 3.07 g, 34.3 mmol), and argon-bubbled N-methylpyrrolidone (NMP, 8 mL) were placed in a 40 mL scintillation vial. The reaction system was flushed with argon for 1 min, quickly capped, and the reaction was stirred at 210 °C for 3 h under argon protection. Upon completion of the reaction, the dark brown easily stirred solution was cooled slightly and subsequently poured into concentrated ammonia (NH4OH, 50 mL) under ice bath conditions with vigorous stirring for 5 min. Dichloromethane (DCM, 50 mL) was added and the bilayer mixture was stirred for an additional 5 minutes and filtered. The lower dark amber colored organic layer was retained and the dark blue aqueous layer was extracted with DCM (2 × 50 mL). All organic layers were combined and washed sequentially with NH4OH (1 × 30 mL) and 4M NaCl solution (1 × 30 mL), then dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give an amber-colored oily material containing a large amount of NMP. The residue was separated by rapid chromatography on silica gel (column: 90 mm × 6 mm; eluent: 6:1 hexane/ethyl acetate; fractions of 100 mL were collected; fractions 15-19 were combined) and rotary evaporated at 40 °C to ultimately yield 5-chloro-3-cyanomethylpyridine as bright white microcrystals (891 mg, 22% yield).
References
[1] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 37
5-CHLORO-3-CYANOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-3-CYANOPYRIDINE manufacturers
- Product
- 5-CHLORO-3-CYANOPYRIDINE 51269-82-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27
- Product
- 5-CHLORO-3-CYANOPYRIDINE 51269-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CHLORO-3-CYANOPYRIDINE 51269-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09