2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- Product Name
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- CAS No.
- 91591-63-8
- Chemical Name
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- Synonyms
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE;3-Cyano-2,5-dichloro-4,6-dimethylpyridine;2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%;2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-;2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
- CBNumber
- CB5352041
- Molecular Formula
- C8H6Cl2N2
- Formula Weight
- 201.05
- MOL File
- 91591-63-8.mol
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Property
- Melting point:
- 82 °C
- Boiling point:
- 304.6±37.0 °C(Predicted)
- Density
- 1.36
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -2.79±0.10(Predicted)
- color
- White
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D434275
- Product name
- 2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile
- Packaging
- 10g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- FD04336
- Product name
- 2,5-Dichloro-4,6-dimethylnicotinonitrile
- Packaging
- 25g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- W9486
- Product name
- 2,5-Dichloro-4,6-dimethylnicotinonitrile
- Packaging
- 100g
- Price
- $531
- Updated
- 2021/12/16
- Product number
- HCH0017821
- Product name
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $649.11
- Updated
- 2021/12/16
- Product number
- HCH0017821
- Product name
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1471.47
- Updated
- 2021/12/16
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Chemical Properties,Usage,Production
Uses
2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Synthesis
Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE manufacturers
- Product
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 91591-63-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2023-05-08
- Product
- 2,5-Dichloro-4,6-dimethylnicotinonitrile 91591-63-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2,5-Dichloro-4,6-Dimethylnicotinonitrile 91591-63-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 100tons
- Release date
- 2021-12-20