ChemicalBook > CAS DataBase List > 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE

Product Name
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
CAS No.
91591-63-8
Chemical Name
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
Synonyms
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE;3-Cyano-2,5-dichloro-4,6-dimethylpyridine;2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%;2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-;2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
CBNumber
CB5352041
Molecular Formula
C8H6Cl2N2
Formula Weight
201.05
MOL File
91591-63-8.mol
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2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Property

Melting point:
82 °C
Boiling point:
304.6±37.0 °C(Predicted)
Density 
1.36
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-2.79±0.10(Predicted)
color 
White
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D434275
Product name
2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile
Packaging
10g
Price
$415
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD04336
Product name
2,5-Dichloro-4,6-dimethylnicotinonitrile
Packaging
25g
Price
$500
Updated
2021/12/16
AK Scientific
Product number
W9486
Product name
2,5-Dichloro-4,6-dimethylnicotinonitrile
Packaging
100g
Price
$531
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0017821
Product name
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
Purity
95.00%
Packaging
1G
Price
$649.11
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0017821
Product name
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
Purity
95.00%
Packaging
10G
Price
$1471.47
Updated
2021/12/16
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2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Chemical Properties,Usage,Production

Uses

2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

Synthesis


Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Suppliers

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View Lastest Price from 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE manufacturers

Chongqing Chemdad Co., Ltd
Product
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 91591-63-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2023-05-08
Henan Aochuang Chemical Co.,Ltd.
Product
2,5-Dichloro-4,6-dimethylnicotinonitrile 91591-63-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Qiuxian Baitai New Material Co., LTD
Product
2,5-Dichloro-4,6-Dimethylnicotinonitrile 91591-63-8
Price
US $10.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100tons
Release date
2021-12-20

91591-63-8, 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILERelated Search:

2-Chloro-4-methylpyridine-3-carbonitrile 2-Chloro-6-methyl-3-pyridinecarbonitrile 4,6-DIMETHYLNICOTINONITRILE 3-CHLORO-5-METHYLPYRIDINE 3-CHLORO-2-METHYLPYRIDINE 3-CHLORO-4-METHYLPYRIDINE 3-Cyanopyridine 2-Chloro-3-cyano-4,6-dimethylpyridine 2-Chloro-3-cyanopyridine 3-Cyano-4-methylpyridine 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 2,5-Dichloropyridine 2,5-DICHLORO-3-PICOLINE 2-Chloro-3-picoline 6-Chloro-2-picoline 2,5-DICHLORO-4-METHYLPYRIDINE 2-Chloro-4-picoline 5-CHLORO-3-CYANOPYRIDINE

  • 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
  • 2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE
  • 2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
  • 2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile
  • 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
  • 2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%
  • 3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-
  • 91591-63-8