XL 228

Product Name: XL 228
CAS No.: 898280-07-4
Chemical Name: XL 228
Synonyms: XL228;XL-228;XL 228;CS-1050;XL228, >=98%;XL228; XL 228;Inhibitor,Bcr-Abl,Aurora Kinase,Src,XL228,IGF-1R,inhibit,XL 228,XL-228;N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine;N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-2,4-pyrimidinediamine;2,4-Pyrimidinediamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-
CBNumber: CB02666701
Molecular Formula: C22H31N9O
Formula Weight: 437.54
MOL File: 898280-07-4.mol

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XL 228 Property

storage temp.: Store at -20°C
solubility: ≥21.9 mg/mL in DMSO; insoluble in H2O; ≥27.6 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21506
Product name: XL228
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21506
Product name: XL228
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 21506
Product name: XL228
Purity: ≥98%
Packaging: 25mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 21506
Product name: XL228
Purity: ≥98%
Packaging: 50mg
Price: $576
Updated: 2024/03/01

TRC

Product number: X746000
Product name: XL228
Packaging: 100mg
Price: $625
Updated: 2021/12/16

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XL 228 Chemical Properties,Usage,Production

Uses

XL228 is a multi-targeted protein kinase inhibitor in patients with solid tumors or multiple myeloma. It is a COVID19-related research product.

Biological Activity

xl228, a tyrosine kinase inhibitor, is involved in binding to and inhibiting the activities of multiple tyrosine kinases, such as the insulin-like growth factor 1 receptor (igf1r), src tyrosine kinase, and bcr-abl tyrosine kinase. blockade of these kinases may result in the inhibition of tumor angiogenesis, cell proliferation, and metastasis [1]. xl228 is a multitargeted protein kinase inhibitor targeting igf1r, the aurora kinases, igf-1r, csrc, bcr/abl and src kinases [2].

in vitro

xl228(5-100 nm) reduced cell survival by 10-70% in a dose and time dependent manner and inhibited migration and invasion of two tumors with high propensity to metastasize, fadu and h460. treatment with 50 and 100 nm xl228 abolished the ability of h460, a549 and fadu cells to form colony. at 10 nm, xl228 significantly increased the radiosensitivity of h460, a549 and fadu cells by enhancement factors (ef, at the survival fraction of 0.5) of 1.52, 1.31 and 1.67 respectively. but, in hn-5 cells, sensitization occurred only at 100 nm (ef = 2.27). in hn-5 cells, xl228 (100 nm)incubation induced accumulation of cells at the radiation sensitive g2/m phase of the cell cycle and induced apoptosis in 32% of cells [2].

References

[1] smith d c, britten c, garon e b. a phase i study of xl228, a multitargeted protein kinase inhibitor, in patients with solid tumors or multiple myeloma[j]. j clinoncol, 2010, 28(15s suppl: abstr 3105).
[2] matsumoto f, molkentine d, clary d o, et al. a multi-kinase inhibitor, xl228, enhanced human cancer cell radiosensitivity and suppressed cell invasion and migration[j]. cancer research, 2011, 71(8 supplement): 2487-2487.
[3] smith d c, britten c, clary d o, et al. a phase i study of xl228, a potent igf1r/aurora/src inhibitor, in patients with solid tumors or hematologic malignancies[j]. j clinoncol, 2009, 27(15 suppl): 149s.

XL 228 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL 228 Suppliers

China 52 United States 9 Global 61

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

ChemieTek

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Email: info@chemietek.com
Country: United States
ProdList: 219
Advantage: 50

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

898280-07-4, XL 228Related Search:

XL413 (BMS-863233) BMS-852927 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate XL888 XL-388 XL019 TDZD-8 4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone GDC-0077 AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7 UNC 0631

XL228; XL 228

CS-1050

XL228, >=98%

XL 228

XL228

XL-228

N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-2,4-pyrimidinediamine

2,4-Pyrimidinediamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-

Inhibitor,Bcr-Abl,Aurora Kinase,Src,XL228,IGF-1R,inhibit,XL 228,XL-228

N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

898280-07-4

C22H31N9O