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SR 3029

Product Name
SR 3029
CAS No.
1454585-06-8
Chemical Name
SR 3029
Synonyms
CS-2390;SR-3029;SR-3029, >98%;SR-3029 (SR 3029;SR-3029, 10 mM in DMSO;SR 3029,Inhibitor,SR-3029,Casein Kinase,inhibit;N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-[(6,7-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine;9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-
CBNumber
CB03123142
Molecular Formula
C23H19F3N8O
Formula Weight
480.45
MOL File
1454585-06-8.mol
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SR 3029 Property

Boiling point:
818.7±75.0 °C(Predicted)
Density 
1.62±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml
form 
A solid
pka
8.76±0.30(Predicted)
color 
White to pink
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27048
Product name
SR 3029
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
27048
Product name
SR 3029
Packaging
25mg
Price
$258
Updated
2024/03/01
Cayman Chemical
Product number
27048
Product name
SR 3029
Packaging
10mg
Price
$161
Updated
2024/03/01
Tocris
Product number
5767
Product name
SR3029
Purity
≥98%(HPLC)
Packaging
5
Price
$224
Updated
2021/12/16
TRC
Product number
S684538
Product name
SR-3029
Packaging
10mg
Price
$320
Updated
2021/12/16
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SR 3029 Chemical Properties,Usage,Production

Uses

SR-3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.

in vivo

SR-3029 (20 mg/kg daily i.p.) exibits anti-tumor effects in rthotopic MDA-MB-231, MDA-MB-468 (TNBC), SKBR3 and BT474 (HER2+) tumor xenografts with no overt toxicity in mice. SR-3029 (20 mg/kg daily i.p.) also effectively inhibits the growth of tumor in primary patient-derived xenograft (PDX) models. In addition, SR-3029 (20 mg/kg, i.p.) strongly reduces the expression of nuclear β-catenin in tumors of mice[2].

IC 50

CKIδ: 44 nM (IC50); CDK6/cyclin D3: 427 nM (IC50); CDK6/cyclin D1: 428 nM (IC50); CDK4/cyclin D3: 368 nM (IC50); CDK4/cyclin D1: 576 nM (IC50); FLT3: 3000 nM (IC50)

storage

Store at +4°C

References

[1]. Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
[2]. Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7(318):318ra202.
[3]. ELISABETH PEER. Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition.[J]. Cancers, 2021. DOI:10.3390/cancers13164227.

SR 3029 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 3029 Suppliers

China 76 United Kingdom 1 United States 9 Global 86
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1454585-06-8, SR 3029Related Search:

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  • N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
  • SR-3029
  • N-[(6,7-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine
  • N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
  • CS-2390
  • SR-3029 (SR 3029
  • SR-3029, >98%
  • 9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-
  • SR 3029,Inhibitor,SR-3029,Casein Kinase,inhibit
  • SR-3029, 10 mM in DMSO
  • 1454585-06-8
  • C23H19F3N8O