ChemicalBook > CAS DataBase List > Propargyl-PEG2-acid

Propargyl-PEG2-acid

Product Name
Propargyl-PEG2-acid
CAS No.
1859379-85-3
Chemical Name
Propargyl-PEG2-acid
Synonyms
Alkyne-PEG2-COOH;CAS_1859379-85-3;Propargyl-PEG1-COOH;Propargyl-PEG2-acid;Propargyl-PEG1-C2-COOH;Propyne-PEG1-CH2CH2COOH;3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid;3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid;Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-
CBNumber
CB03163104
Molecular Formula
C8H12O4
Formula Weight
172.18
MOL File
1859379-85-3.mol
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Propargyl-PEG2-acid Property

storage temp. 
-20°C
solubility 
DMSO: 250 mg/mL (1451.97 mM)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901566
Product name
Propargyl-PEG2-acid
Packaging
50MG
Price
$221
Updated
2023/06/20
BroadPharm
Product number
BP-23165
Product name
Propargyl-PEG2-acid
Purity
98%
Packaging
100mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0068466
Product name
Propargyl-PEG2-acid
Purity
≥98.0%
Packaging
100mg
Price
$300
Updated
2021/12/16
Activate Scientific
Product number
AS104183
Product name
3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid
Purity
95+%
Packaging
1g
Price
$439
Updated
2021/12/16
BroadPharm
Product number
BP-23165
Product name
Propargyl-PEG2-acid
Purity
98%
Packaging
250mg
Price
$450
Updated
2021/12/16
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Propargyl-PEG2-acid Chemical Properties,Usage,Production

Description

Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage.

Uses

Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Propargyl-PEG2-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG2-acid Suppliers

China 56 United States 6 Global 62
Daicel Chiral Technologies (China)CO.,LTD
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View Lastest Price from Propargyl-PEG2-acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG2-acid 1859379-85-3
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-26

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  • Propargyl-PEG2-acid
  • Propyne-PEG1-CH2CH2COOH
  • 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid
  • Propargyl-PEG1-COOH
  • CAS_1859379-85-3
  • 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid
  • Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-
  • Propargyl-PEG1-C2-COOH
  • Alkyne-PEG2-COOH
  • 1859379-85-3