N-Boc-PEG4-bromide
- Product Name
- N-Boc-PEG4-bromide
- CAS No.
- 1392499-32-9
- Chemical Name
- N-Boc-PEG4-bromide
- Synonyms
- BocNH-PEG4-Br;Br-PEG4-NHBoc;N-Boc-PEG4-bromide;N-Boc-PEG5-bromide;BocNH-PEG4-CH2CH2Br;N-Boc-PEG4-bromide N-Boc-;tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate;tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate;5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester;ADC,antibody-drug,PROTAC Linkers,ADC Linkers,N-Boc-PEG-5-bromide,cleavable,inhibit,conjugates,Inhibitor,N Boc PEG5 bromide,NBocPEG5bromide,Antibody-drug conjugates linkers
- CBNumber
- CB03373736
- Molecular Formula
- C15H30BrNO6
- Formula Weight
- 400.31
- MOL File
- 1392499-32-9.mol
N-Boc-PEG4-bromide Property
- Boiling point:
- 459.3±40.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- solubility
- Soluble in DCM
- pka
- 12.23±0.46(Predicted)
- form
- Liquid
- color
- Light yellow to brown
N-Bromosuccinimide Price
- Product number
- BP-23789
- Product name
- N-Boc-PEG4-bromide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- AS103627
- Product name
- BocNH-PEG4-CH2CH2Br
- Purity
- 95+%
- Packaging
- 1g
- Price
- $665
- Updated
- 2021/12/16
- Product number
- 0954EB
- Product name
- N-Boc-PEG5-bromide
- Packaging
- 1g
- Price
- $856
- Updated
- 2021/12/16
- Product number
- CD64000172
- Product name
- N-BOc-peg4-bromide
- Purity
- 95%
- Packaging
- 1g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- AC-8220
- Product name
- BocNH-PEG4-CH2CH2Br
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $220
- Updated
- 2021/12/16
N-Boc-PEG4-bromide Chemical Properties,Usage,Production
Description
N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Biological Activity
N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
N-Boc-PEG4-bromide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Boc-PEG4-bromide Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 17777
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
View Lastest Price from N-Boc-PEG4-bromide manufacturers
- Product
- Br-PEG4-NHBoc 1392499-32-9
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-25