Boc-His(Trt)-OH

Product Name: Boc-His(Trt)-OH
CAS No.: 32926-43-5
Chemical Name: Boc-His(Trt)-OH
Synonyms: BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
CBNumber: CB0342634
Molecular Formula: C30H31N3O4
Formula Weight: 497.58
MOL File: 32926-43-5.mol

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Boc-His(Trt)-OH Property

Melting point:: ~130 °C (dec.)
alpha: 12.5 º (C=1% IN MEOH)
Boiling point:: 667.5±55.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Sparingly)
form: Solid
pka: 3.17±0.10(Predicted)
color: White to Off-White
optical activity: [α]20/D +12.5±1.0°, c = 1% in methanol
BRN: 732035
InChIKey: OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES: C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 32926-43-5(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53034
Product name: Boc-His(Trt)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $1340
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15449
Product name: Boc-His(Trt)-OH
Purity: ≥98.0% (TLC)
Packaging: 1g
Price: $42.8
Updated: 2024/03/01

TRC

Product number: B656218
Product name: Boc-His(Trt)-OH
Packaging: 5g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42925
Product name: Boc-His(Trt)-OH
Packaging: 10g
Price: $90
Updated: 2021/12/16

Chem-Impex

Product number: 04038
Product name: Nα-Boc-Nim-trityl-L-histidine,≥99.7%(HPLC,Chiralpurity)
Purity: ≥99.7%(HPLC,Chiralpurity)
Packaging: 5G
Price: $93.18
Updated: 2021/12/16

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Boc-His(Trt)-OH Chemical Properties,Usage,Production

Chemical Properties

White to off white powder

Uses

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

Uses

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Preparation

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et₂O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

Application

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-His(Trt)-OH Suppliers

China 213 Germany 4 India 3 Japan 2 Switzerland 2 United Kingdom 4 United States 21 Global 249

ChemPep, Inc.

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View Lastest Price from Boc-His(Trt)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-His(trt)-OH 32926-43-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%;99%
Supply Ability: 1T+
Release date: 2024-02-23

Henan Fengda Chemical Co., Ltd

Product: Boc-His(Trt)-OH 32926-43-5
Price: US $8.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Boc-N"-trityl-L-histidine 32926-43-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

32926-43-5, Boc-His(Trt)-OHRelated Search:

Trityl candesartan cilexetil p-Toluic acid L-Histidine N-Boc-L-Histidine N-Carbobenzyloxyglycine Triphenylmethyl Chloride PENICILLIN V Boc-Aib-OH N-Boc-N'-Cbz-L-lysine N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine BOC-GLY-LEU-OH Toluene (-)-2-[METHYLAMINO]-1-PHENYLPROPANE 1-Triphenylmethyl-4-methylimidazole BOC-HIS(BZL)-OH H-HIS(BZL)-OH

(S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid

(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid

Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine

Boc-L-His(Trt)

N-Boc-His(Trt)-OH

(S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95%

His(Trt)-OH

Boc-His(Trt)-OH >=98.0% (TLC)

Boc-His(Trt)-OH, >=98%

(S)-L-Boc-his(trt)-oh

BOC-L-HIS(TRT)-OH

BOC-N-IM-TRITYL-L-HISTIDINE

BOC-HIS(TRT)-OH

N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE

N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE

N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE

N<sub>α</sub>-Boc-N(im)-trityl-L-histidine

Boc-His(trt)

N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE

L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-

Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)

N-Boc-N'-trityl-L-histidine

(Tert-Butoxy)Carbonyl His(Trt)-OH

2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID

N-Boc-N'-trityl-L-histidine USP/EP/BP

Nα-Boc-Nim-trityl-L-histidine

N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine

(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid

N-Boc N '- Triphenylmethyl L-histidine

Na-(tert-butoxycarbonyl)-N-trityl-L-histidine

N-Boc-N'-triphenylmethyl-L-histidine

Impurity HA-1

32926-43-5

C30H31N3O4

Amino Acid Derivatives

Histidine

Peptide Synthesis

Specialty Synthesis

Boc-Amino Acids and Derivative

Boc-Amino acid series