ChemicalBook > CAS DataBase List > 1,3,5-Trimethoxybenzene

1,3,5-Trimethoxybenzene

Product Name: 1,3,5-Trimethoxybenzene
CAS No.: 621-23-8
Chemical Name: 1,3,5-Trimethoxybenzene
Synonyms: Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
CBNumber: CB0371005
Molecular Formula: C9H12O3
Formula Weight: 168.19
MOL File: 621-23-8.mol

Less

1,3,5-Trimethoxybenzene Property

Melting point:: 50-53 °C (lit.)
Boiling point:: 255 °C (lit.)
Density: 1,126g/cm
refractive index: 1,533
Flash point:: 186 °F
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: 0.1 g/mL, clear, colorless
form: Crystalline Powder
color: White to cream
Water Solubility: insoluble
BRN: 1307993
InChIKey: LKUDPHPHKOZXCD-UHFFFAOYSA-N
LogP: 1.605 (est)
CAS DataBase Reference: 621-23-8(CAS DataBase Reference)
NIST Chemistry Reference: 1,3,5-Trimethoxybenzene(621-23-8)
EPA Substance Registry System: 1,3,5-Trimethoxybenzene (621-23-8)

Less

Safety

Hazard Codes: Xn,F
Risk Statements: 22-20/21/22
Safety Statements: 24/25-36-26
RIDADR: 1325
WGK Germany: 3
RTECS: DC2810000
Hazard Note: Flammable Solid/Harmful
TSCA: Yes
HazardClass: 4.1
PackingGroup: III
HS Code: 29093090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 138827
Product name: 1,3,5-Trimethoxybenzene
Purity: ReagentPlus , ≥99%
Packaging: 10g
Price: $37.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 138827
Product name: 1,3,5-Trimethoxybenzene
Purity: ReagentPlus , ≥99%
Packaging: 50g
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: P0250
Product name: 1,3,5-Trimethoxybenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: P0250
Product name: 1,3,5-Trimethoxybenzene
Purity: >98.0%(GC)
Packaging: 100g
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: 74599
Product name: 1,3,5-Trimethoxybenzene
Purity: Standard for quantitative NMR, TraceCERT
Packaging: 1g
Price: $181
Updated: 2025/07/31

Less

1,3,5-Trimethoxybenzene Chemical Properties,Usage,Production

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

Reactions

1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one^[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates^[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling^[3].

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

References

[1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Br?nsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662.

1,3,5-Trimethoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1,3,5-Trimethoxybenzene Suppliers

Americas 1 Belgium 3 Canada 4 China 485 Europe 3 France 3 Germany 10 India 28 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 Ukraine 2 United Kingdom 18 United States 53 USA 1 Global 624

Zhejiang zetian fine chemical co. LTD

Tel: 0571-87322520 18957127338
Fax: QQ:800182836
Email: sales@zetchem.com
Country: China
ProdList: 445
Advantage: 58

Zhejiang Karry Pharmachem Co., Ltd.

Tel: 19157666807
Email: info@karrypharma.com
Country: China
ProdList: 39
Advantage: 58

HANGZHOU KINSOCHEM PHARMA CO.,LTD

Tel: 0571-56950601,56950602 15957107654
Fax: 0571-56950610
Email: 951594434@qq.com
Country: China
ProdList: 46
Advantage: 55

Beijing Wisdom Chemicals Co., Ltd.

Tel: 010-59777827 13701052487
Email: sales1@wisdomchem.com
Country: China
ProdList: 245
Advantage: 58

Zheda Panaco Chemical Engineering Co., Ltd

Tel: 0571-86770761
Fax: +0571-87984136
Email: zhedapanaco02@zhedachem.com
Country: China
ProdList: 100
Advantage: 60

Shandong Chengwu Zeda General Chemical Co., Ltd.

Tel: 0530-8865559
Fax: +0571-87984136
Email: zhedapanaco02@zhedachem.com
Country: China
ProdList: 171
Advantage: 58

Dezhou Honghai Pharmaceutical Technology Co., Ltd

Tel: +86-13285346120 13285346120
Email: 17658510842@163.com
Country: China
ProdList: 46
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1390
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85105512 17802830247
Email: baozuqiang@d-innovation.com
Country: China
ProdList: 60
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1972
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Beijin Yangguang Furui Chemical co.,Ltd.

Tel: 010-57495520 13521095525
Email: zhw512@foxmail.com
Country: China
ProdList: 488
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Less

View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 TON
Release date: 2024-11-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

621-23-8, 1,3,5-TrimethoxybenzeneRelated Search:

Anisole Ethylbenzene PETROLEUM ETHER o-Anisaldehyde Trimethyl phosphite 3,4,5-Trimethoxyphenol (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 2-Butoxyethanol m-Anisyl alcohol (Trifluoromethoxy)benzene Phloroglucinol p-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE Trimethyl borate 3,4,5-Trimethoxy benzoic acid Dimethyl ether Trimethylphloroglucinol

1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%

PHLOROGLUCINOL TRIMETHYL ETHER

TRISMETHOXYBENZENE

1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%

1,3,5-Methoxybenzene

1,3,5-TriMetho

1,3,5-trimethoxy-benzen

1,3,5-Trimethyoxybenzene

Benzene, 1,3,5-trimethoxy-

3,5-DIMETHOXYANISOLE

1,3,5-TRIMETHOXYBENZENE

1,3,5-Trimethoxybenzene/Phloroglucinol trimethyl ether

O,O,O-1,3,5-trimethylresorcinol

1,3,5-TRIMETHOXYBENZENE, 99+%

1,3,5-TrimethoxybenzeneC9H12O3

1,3,5-TRIMETHOXYBENZENE pure

1,3,5-Trimethoxybenzene (TMB)

1,3,5-Trimethoxybenz

5-TriMethoxybenzene

Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole

1,3,5-TriMethoxybenzene, 99% 10GR

sym-Trimethoxybenzene

2,4,6-Trimethoxybenzene

1,3,5-Trimethoxybenzene&gt

1,3,5-Trimethoxybenzene Standard

O,O,O-1,3,5-Trimethylresorcin

1,3,5-Trimethoxybenzene ISO 9001：2015 REACH

Trimethy phloroglucinol

1,3,5-Trimethoxybenzene, 10 mM in DMSO

1,3,5-Trimethoxybenzene, 98%

l,3,5-Trimethoxy-Benzene

621-23-8

621-23-08

621-2308

C9H12O3

Organic Building Blocks

Building Blocks

Oxygen Compounds

Ethers

Benzene derivates

Aromatic Ethers

ACTIVE PHARMACEUTICAL INGREDIENTS

621-23-8

API