1,3,5-Trimethoxybenzene

Product Name: 1,3,5-Trimethoxybenzene
CAS No.: 621-23-8
Chemical Name: 1,3,5-Trimethoxybenzene
Synonyms: Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
CBNumber: CB0371005
Molecular Formula: C9H12O3
Formula Weight: 168.19
MOL File: 621-23-8.mol

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1,3,5-Trimethoxybenzene Property

Melting point:: 50-53 °C (lit.)
Boiling point:: 255 °C (lit.)
Density: 1,126g/cm
refractive index: 1,533
Flash point:: 186 °F
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: 0.1 g/mL, clear, colorless
form: Crystalline Powder
color: White to cream
Water Solubility: insoluble
BRN: 1307993
InChIKey: LKUDPHPHKOZXCD-UHFFFAOYSA-N
LogP: 1.605 (est)
CAS DataBase Reference: 621-23-8(CAS DataBase Reference)
NIST Chemistry Reference: 1,3,5-Trimethoxybenzene(621-23-8)
EPA Substance Registry System: 1,3,5-Trimethoxybenzene (621-23-8)

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Safety

Hazard Codes: Xn,F
Risk Statements: 22-20/21/22
Safety Statements: 24/25-36-26
RIDADR: 1325
WGK Germany: 3
RTECS: DC2810000
Hazard Note: Flammable Solid/Harmful
TSCA: Yes
HazardClass: 4.1
PackingGroup: III
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 138827
Product name: 1,3,5-Trimethoxybenzene
Purity: ReagentPlus , ≥99%
Packaging: 10g
Price: $37.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 138827
Product name: 1,3,5-Trimethoxybenzene
Purity: ReagentPlus , ≥99%
Packaging: 50g
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: P0250
Product name: 1,3,5-Trimethoxybenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: P0250
Product name: 1,3,5-Trimethoxybenzene
Purity: >98.0%(GC)
Packaging: 100g
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: 74599
Product name: 1,3,5-Trimethoxybenzene
Purity: Standard for quantitative NMR, TraceCERT
Packaging: 1g
Price: $181
Updated: 2025/07/31

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1,3,5-Trimethoxybenzene Chemical Properties,Usage,Production

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

Reactions

1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one^[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates^[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling^[3].

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

References

[1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Br?nsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662.

1,3,5-Trimethoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 TON
Release date: 2024-11-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3,5-Trimethoxybenzene 621-23-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

621-23-8, 1,3,5-TrimethoxybenzeneRelated Search:

Anisole Ethylbenzene PETROLEUM ETHER o-Anisaldehyde Trimethyl phosphite 3,4,5-Trimethoxyphenol (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 2-Butoxyethanol m-Anisyl alcohol (Trifluoromethoxy)benzene Phloroglucinol p-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE Trimethyl borate 3,4,5-Trimethoxy benzoic acid Dimethyl ether Trimethylphloroglucinol

1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%

PHLOROGLUCINOL TRIMETHYL ETHER

TRISMETHOXYBENZENE

1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%

1,3,5-Methoxybenzene

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1,3,5-TRIMETHOXYBENZENE, 99+%

1,3,5-TrimethoxybenzeneC9H12O3

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1,3,5-Trimethoxybenzene (TMB)

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5-TriMethoxybenzene

Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole

1,3,5-TriMethoxybenzene, 99% 10GR

sym-Trimethoxybenzene

2,4,6-Trimethoxybenzene

1,3,5-Trimethoxybenzene&gt

1,3,5-Trimethoxybenzene Standard

O,O,O-1,3,5-Trimethylresorcin

1,3,5-Trimethoxybenzene ISO 9001：2015 REACH

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1,3,5-Trimethoxybenzene, 10 mM in DMSO

1,3,5-Trimethoxybenzene, 98%

l,3,5-Trimethoxy-Benzene

621-23-8

621-23-08

621-2308

C9H12O3

Organic Building Blocks

Building Blocks

Oxygen Compounds

Ethers

Benzene derivates

Aromatic Ethers

ACTIVE PHARMACEUTICAL INGREDIENTS

621-23-8

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