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1,3,5-Trimethoxybenzene

Product Name
1,3,5-Trimethoxybenzene
CAS No.
621-23-8
Chemical Name
1,3,5-Trimethoxybenzene
Synonyms
Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
CBNumber
CB0371005
Molecular Formula
C9H12O3
Formula Weight
168.19
MOL File
621-23-8.mol
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1,3,5-Trimethoxybenzene Property

Melting point:
50-53 °C (lit.)
Boiling point:
255 °C (lit.)
Density 
1,126g/cm
refractive index 
1,533
Flash point:
186 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White to cream
Water Solubility 
insoluble
BRN 
1307993
InChIKey
LKUDPHPHKOZXCD-UHFFFAOYSA-N
LogP
1.605 (est)
CAS DataBase Reference
621-23-8(CAS DataBase Reference)
NIST Chemistry Reference
1,3,5-Trimethoxybenzene(621-23-8)
EPA Substance Registry System
1,3,5-Trimethoxybenzene (621-23-8)
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Safety

Hazard Codes 
Xn,F
Risk Statements 
22-20/21/22
Safety Statements 
24/25-36-26
RIDADR 
1325
WGK Germany 
3
RTECS 
DC2810000
Hazard Note 
Flammable Solid/Harmful
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
10g
Price
$37.1
Updated
2025/07/31
Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
50g
Price
$113
Updated
2025/07/31
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
100g
Price
$125
Updated
2025/07/31
Sigma-Aldrich
Product number
74599
Product name
1,3,5-Trimethoxybenzene
Purity
Standard for quantitative NMR, TraceCERT
Packaging
1g
Price
$181
Updated
2025/07/31
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1,3,5-Trimethoxybenzene Chemical Properties,Usage,Production

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

Reactions

1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling[3].

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

References

[1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Br?nsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662.

1,3,5-Trimethoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5-Trimethoxybenzene Suppliers

Americas 1 Belgium 3 Canada 4 China 485 Europe 3 France 3 Germany 10 India 28 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 Ukraine 2 United Kingdom 18 United States 53 USA 1 Global 624
BIESTERFELD SPEZIALCHEMIE GMBH
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View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 TON
Release date
2024-11-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Henan Aochuang Chemical Co.,Ltd.
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29

621-23-8, 1,3,5-TrimethoxybenzeneRelated Search:

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