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1,3,5-Trimethoxybenzene

Product Name
1,3,5-Trimethoxybenzene
CAS No.
621-23-8
Chemical Name
1,3,5-Trimethoxybenzene
Synonyms
Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
CBNumber
CB0371005
Molecular Formula
C9H12O3
Formula Weight
168.19
MOL File
621-23-8.mol
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1,3,5-Trimethoxybenzene Property

Melting point:
50-53 °C (lit.)
Boiling point:
255 °C (lit.)
Density 
1,126g/cm
refractive index 
1,533
Flash point:
186 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White to cream
Water Solubility 
insoluble
BRN 
1307993
InChIKey
LKUDPHPHKOZXCD-UHFFFAOYSA-N
LogP
1.605 (est)
CAS DataBase Reference
621-23-8(CAS DataBase Reference)
NIST Chemistry Reference
1,3,5-Trimethoxybenzene(621-23-8)
EPA Substance Registry System
1,3,5-Trimethoxybenzene (621-23-8)
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Safety

Hazard Codes 
Xn,F
Risk Statements 
22-20/21/22
Safety Statements 
24/25-36-26
RIDADR 
1325
WGK Germany 
3
RTECS 
DC2810000
Hazard Note 
Flammable Solid/Harmful
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
10g
Price
$36
Updated
2024/03/01
Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
50g
Price
$110
Updated
2024/03/01
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$37
Updated
2024/03/01
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
100g
Price
$111
Updated
2024/03/01
Alfa Aesar
Product number
A13981
Product name
1,3,5-Trimethoxybenzene, 99%
Packaging
10g
Price
$32.4
Updated
2024/03/01
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1,3,5-Trimethoxybenzene Chemical Properties,Usage,Production

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

1,3,5-Trimethoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5-Trimethoxybenzene Suppliers

Americas 1 Belgium 3 Canada 4 China 454 Europe 3 France 3 Germany 10 India 28 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 Ukraine 2 United Kingdom 18 United States 53 USA 1 Global 593
Fischer Chemicals AG
Tel
--
Fax
--
Email
contact@fischer-group.ch
Country
Switzerland
ProdList
411
Advantage
58
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Le Chem Organics SA
Tel
--
Fax
--
Email
info@lechem.com
Country
Switzerland
ProdList
196
Advantage
43
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Hebei Weibang Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 TON
Release date
2024-11-01
Hebei Yanxi Chemical Co., Ltd.
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $20.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20mt/mon
Release date
2023-09-04

621-23-8, 1,3,5-TrimethoxybenzeneRelated Search:

Anisole Ethylbenzene PETROLEUM ETHER o-Anisaldehyde Trimethyl phosphite 3,4,5-Trimethoxyphenol (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 2-Butoxyethanol m-Anisyl alcohol (Trifluoromethoxy)benzene Phloroglucinol p-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE Trimethyl borate 3,4,5-Trimethoxy benzoic acid Dimethyl ether Trimethylphloroglucinol

  • 1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%
  • PHLOROGLUCINOL TRIMETHYL ETHER
  • TRISMETHOXYBENZENE
  • 1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%
  • 1,3,5-Methoxybenzene
  • 1,3,5-TriMetho
  • 1,3,5-trimethoxy-benzen
  • 1,3,5-Trimethyoxybenzene
  • Benzene, 1,3,5-trimethoxy-
  • 3,5-DIMETHOXYANISOLE
  • 1,3,5-TRIMETHOXYBENZENE
  • 1,3,5-Trimethoxybenzene/Phloroglucinol trimethyl ether
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  • 1,3,5-TRIMETHOXYBENZENE, 99+%
  • 1,3,5-TrimethoxybenzeneC9H12O3
  • 1,3,5-TRIMETHOXYBENZENE pure
  • 1,3,5-Trimethoxybenzene (TMB)
  • 1,3,5-Trimethoxybenz
  • 5-TriMethoxybenzene
  • Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole
  • 1,3,5-TriMethoxybenzene, 99% 10GR
  • sym-Trimethoxybenzene
  • 2,4,6-Trimethoxybenzene
  • 1,3,5-Trimethoxybenzene&gt
  • 1,3,5-Trimethoxybenzene Standard
  • O,O,O-1,3,5-Trimethylresorcin
  • 1,3,5-Trimethoxybenzene ISO 9001：2015 REACH
  • Trimethy phloroglucinol
  • 621-23-8
  • 621-23-08
  • 621-2308
  • C9H12O3
  • Organic Building Blocks
  • Building Blocks
  • Oxygen Compounds
  • Ethers
  • Benzene derivates
  • Aromatic Ethers
  • ACTIVE PHARMACEUTICAL INGREDIENTS
  • 621-23-8
  • API