2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 170491-63-1
- Chemical Name
- 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- AKOS 92835;BOC-DL-PRO-AL;Boc-DL-Pro-OL;N-Boc-Prolinol;Boc-DL-Prolinol;CAS:170491-63-1;N-Boc-DL-prolinol;1-Boc-2-pyrrolidineMethanol;N-Boc-2-pyrrolidineMethanol;(±)-1-Boc-pyrrolidine-2-Methanol
- CBNumber
- CB0476463
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 170491-63-1.mol
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Melting point:
- 52-54℃
- Boiling point:
- 290℃
- Density
- 1.084
- Flash point:
- 129℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 14.77±0.10(Predicted)
- color
- White to Almost white
- InChIKey
- BFFLLBPMZCIGRM-UHFFFAOYSA-N
- CAS DataBase Reference
- 170491-63-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3273
- Product name
- N-(tert-Butoxycarbonyl)-DL-prolinol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- B3273
- Product name
- N-(tert-Butoxycarbonyl)-DL-prolinol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- B689485
- Product name
- N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol
- Packaging
- 25g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- W3719
- Product name
- 1-Boc-(2-Hydroxymethyl)pyrrolidine
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 43814
- Product name
- N-(tert-Butoxycarbonyl)-DL-prolinol,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $26.58
- Updated
- 2021/12/16
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol is used to prepare 1,3-thiazolidin-2-imines derivatives as inhibitors of nitric oxide synthase.
Synthesis
24424-99-5
498-63-5
170491-63-1
Step 1. Synthesis of tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate Pyrrolidine-2-methanol (0.300 g, 1.98 mmol) was dissolved in dichloromethane (5.0 mL) and di-tert-butyl dicarbonate (0.650 g, 1.98 mmol) was added. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the residue was purified by post-processing using Isco Combi-Flash Companion column chromatography (eluent: dichloromethane solution in 0-10% methanol) to afford tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate (0.590 g, 98% yield). 1H NMR (CDCl3, 300 MHz) δ 4.78 (br d, 1H), 4.05-3.90 (br, 1H), 3.67-3.53 (m, 2H), 3.49-3.41 (m, 1H), 3.34-3.26 (m, 1H), 2.00 (dddd, 1H), 1.85-1.72 (m, 2H). 1.60-1.50 (m, 1H), 1.46 (s, 9H).
References
[1] Patent: US2017/253569, 2017, A1. Location in patent: Paragraph 0994-0995
[2] Tetrahedron, 2005, vol. 61, # 10, p. 2631 - 2643
[3] Patent: US2016/168090, 2016, A1. Location in patent: Paragraph 0823-0824
[4] Patent: WO2011/22508, 2011, A2. Location in patent: Page/Page column 59; 60
[5] Patent: EP2202223, 2010, A1. Location in patent: Page/Page column 72-73
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 1-Boc-2-pyrrolidinemethanol 170491-63-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 1-Boc-2-pyrrolidinemethanol 170491-63-1
- Price
- US $100.00-2.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-05
- Product
- 1-BOC-(2-HYDROXYMETHYL)PYRROLIDINE 170491-63-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2020-12-24