PROTAC FAK degrader 1

Product Name: PROTAC FAK degrader 1
CAS No.: 2301916-69-6
Chemical Name: PROTAC FAK degrader 1
Synonyms: PROTAC FAK degrader 1;(2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(2-(4-((4-((3-(N-methylmethylsulfonamido)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenoxy)ethoxy)propanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-{3-[2-(4-{[4-({[3-(N-methylmethanesulfonamido)phenyl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenoxy)ethoxy]propanamido}butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB05848999
Molecular Formula: C47H56F3N9O8S2
Formula Weight: 996.13
MOL File: 2301916-69-6.mol

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PROTAC FAK degrader 1 Property

Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 200 mg/mL (200.78 mM)
pka: 14.07±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0078799
Product name: PROTACFAKdegrader1
Purity: 99.91%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0078799
Product name: PROTACFAKdegrader1
Purity: 99.91%
Packaging: 5mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0078799
Product name: PROTACFAKdegrader1
Purity: 99.91%
Packaging: 10mg
Price: $1500
Updated: 2021/12/16

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PROTAC FAK degrader 1 Chemical Properties,Usage,Production

Description

PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM[1]. IC50: 6.5 nM (Focal adhesion kinase)DC50: 3 nM (Focal adhesion kinase)[1]

Uses

PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor. (Pink: Fak ligand (HY-44146); Black: Linker (HY-44141); Blue: VHL ligand 1 (HY-125845))[1].

References

[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.

PROTAC FAK degrader 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC FAK degrader 1 Suppliers

China 16 United States 1 Global 17

Bide Pharmatech Ltd.

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Henan Inokai New Materials Co., Ltd

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PROTAC FAK degrader 1

(2S,4R)-1-[(2S)-3,3-dimethyl-2-{3-[2-(4-{[4-({[3-(N-methylmethanesulfonamido)phenyl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenoxy)ethoxy]propanamido}butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(2-(4-((4-((3-(N-methylmethylsulfonamido)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenoxy)ethoxy)propanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

2301916-69-6