ChemicalBook > CAS DataBase List > CHOLERA TOXIN

CHOLERA TOXIN

Product Name
CHOLERA TOXIN
CAS No.
9012-63-9
Chemical Name
CHOLERA TOXIN
Synonyms
Cholergen;choleragen;CHOLERA TOXIN;Choleragenoid;choleraexotoxin;exo-enterotoxin;Toxins, cholera;CHOLERA ENTEROTOXIN;VIBRIO CHOLERAE TOXIN;choleraentero-exotoxin
CBNumber
CB0683337
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
More
Less

CHOLERA TOXIN Property

storage temp. 
0-6°C
solubility 
H2O: soluble10mg/mL
form 
lyophilized powder
color 
White to off-white
More
Less

Safety

Hazard Codes 
T
Risk Statements 
24/25-52/53
Safety Statements 
36/37-45-61
RIDADR 
3172
WGK Germany 
2
RTECS 
LF3100000
HazardClass 
6.1
PackingGroup 
I
Toxicity
cholera toxin is secreted by the gram-negative bacterium Vibrio cholerae. It is a gastrointestinal toxin that increases adenylate cyclase activity of mucosa of the small intestine, thereby increasing cyclic AMP within these cells. Cyclic AMP stimulates active transport of ions by these epithelial cells, resulting in a large efflux of Na+ and water into the gut. The toxin enters cells by interacting with a GM1 ganglioside on the cell surface. After entry, the A1 subunit catalyzes the transfer of an ADP-ribose unit from NAD+ to an arginine side chain of the adenylate cyclase regulatory G protein, blocking its GTPase activity. Thus the adenylate cyclase deactivation mechanism is destroyed, and cyclic AMP is continually produced. The major sign of cholera poisoning is severe diarrhea; several liters of body water may be lost within a few hours, leading to shock and death if fluid is not replaced. Treatment involves physiological support (including i.v. fluids) and antibiotics.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8052
Product name
Cholera Toxin from Vibrio cholerae
Purity
≥90% (SDS-PAGE), lyophilized powder
Packaging
0.5mg
Price
$171
Updated
2024/03/01
Sigma-Aldrich
Product number
C8052
Product name
Cholera Toxin from Vibrio cholerae
Purity
~95% (SDS-PAGE)
Packaging
1mg
Price
$296
Updated
2024/03/01
Sigma-Aldrich
Product number
227036
Product name
CholeraToxin,Vibriocholerae,TypeInaba569B,AzideFree-CAS9012-63-9-Calbiochem
Purity
CholeratoxinInaba569B,CAS9012-63-9,hasasingleAsubunitsurroundedbyfi
Packaging
1mg
Price
$297
Updated
2024/03/01
Cayman Chemical
Product number
23217
Product name
Cholera Toxin from Vibrio cholerae
Purity
≥95% (estimated by SDS-PAGE)
Packaging
2mg
Price
$357
Updated
2021/12/16
Cayman Chemical
Product number
23217
Product name
Cholera Toxin from Vibrio cholerae
Purity
≥95% (estimated by SDS-PAGE)
Packaging
1mg
Price
$188
Updated
2021/12/16
More
Less

CHOLERA TOXIN Chemical Properties,Usage,Production

Uses

Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.

Biochem/physiol Actions

Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.

CHOLERA TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CHOLERA TOXIN Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30241
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Hubei Enxing Biotechnology Co., Ltd
Tel
16621771607
Email
exbio_tech@163.com
Country
China
ProdList
8228
Advantage
58
G-CLONE
Tel
400-910-1997 17560619001
Email
3243204476@qq.com
Country
China
ProdList
9959
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb5@aikonchem.com
Country
China
ProdList
10528
Advantage
58

9012-63-9, CHOLERA TOXINRelated Search:


  • Choleragenoid
  • Cholera Toxin from Vibrio cholerae,Cholera enterotoxin, Cholergen
  • Cholergen
  • CHOLERA TOXIN
  • CHOLERA ENTEROTOXIN
  • CHOLERA TOXIN, VIBRIO CHOLERAE, TYPE INABA 569B
  • VIBRIO CHOLERAE TOXIN
  • choleraentero-exotoxin
  • choleraexotoxin
  • choleragen
  • exo-enterotoxin
  • exotoxin,vibriocholerae
  • CHOLERA TOXIN FROM VIBRIO CHOLERAE
  • Toxins, cholera
  • 9012-63-9
  • G Protein Function
  • G Proteins and Cyclic Nucleotides
  • Reagents
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology