CHOLERA TOXIN
- Product Name
- CHOLERA TOXIN
- CAS No.
- 9012-63-9
- Chemical Name
- CHOLERA TOXIN
- Synonyms
- Cholergen;choleragen;CHOLERA TOXIN;Choleragenoid;choleraexotoxin;exo-enterotoxin;Toxins, cholera;CHOLERA ENTEROTOXIN;VIBRIO CHOLERAE TOXIN;choleraentero-exotoxin
- CBNumber
- CB0683337
- Molecular Formula
- NULL
- Formula Weight
- 0
- MOL File
- Mol file
CHOLERA TOXIN Property
- storage temp.
- 0-6°C
- solubility
- H2O: soluble10mg/mL
- form
- lyophilized powder
- color
- White to off-white
Safety
- Hazard Codes
- T
- Risk Statements
- 24/25-52/53
- Safety Statements
- 36/37-45-61
- RIDADR
- 3172
- WGK Germany
- 2
- RTECS
- LF3100000
- HazardClass
- 6.1
- PackingGroup
- I
- Toxicity
- cholera toxin is secreted by the gram-negative bacterium Vibrio cholerae. It is a gastrointestinal toxin that increases adenylate cyclase activity of mucosa of the small intestine, thereby increasing cyclic AMP within these cells. Cyclic AMP stimulates active transport of ions by these epithelial cells, resulting in a large efflux of Na+ and water into the gut. The toxin enters cells by interacting with a GM1 ganglioside on the cell surface. After entry, the A1 subunit catalyzes the transfer of an ADP-ribose unit from NAD+ to an arginine side chain of the adenylate cyclase regulatory G protein, blocking its GTPase activity. Thus the adenylate cyclase deactivation mechanism is destroyed, and cyclic AMP is continually produced. The major sign of cholera poisoning is severe diarrhea; several liters of body water may be lost within a few hours, leading to shock and death if fluid is not replaced. Treatment involves physiological support (including i.v. fluids) and antibiotics.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H332Harmful if inhaled
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C8052
- Product name
- Cholera Toxin from Vibrio cholerae
- Purity
- ≥90% (SDS-PAGE), lyophilized powder
- Packaging
- 0.5mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- C8052
- Product name
- Cholera Toxin from Vibrio cholerae
- Purity
- ~95% (SDS-PAGE)
- Packaging
- 1mg
- Price
- $296
- Updated
- 2024/03/01
- Product number
- 227036
- Product name
- CholeraToxin,Vibriocholerae,TypeInaba569B,AzideFree-CAS9012-63-9-Calbiochem
- Purity
- CholeratoxinInaba569B,CAS9012-63-9,hasasingleAsubunitsurroundedbyfi
- Packaging
- 1mg
- Price
- $297
- Updated
- 2024/03/01
- Product number
- 23217
- Product name
- Cholera Toxin from Vibrio cholerae
- Purity
- ≥95% (estimated by SDS-PAGE)
- Packaging
- 2mg
- Price
- $357
- Updated
- 2021/12/16
- Product number
- 23217
- Product name
- Cholera Toxin from Vibrio cholerae
- Purity
- ≥95% (estimated by SDS-PAGE)
- Packaging
- 1mg
- Price
- $188
- Updated
- 2021/12/16
CHOLERA TOXIN Chemical Properties,Usage,Production
Uses
Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.
Biochem/physiol Actions
Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
CHOLERA TOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
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