ChemicalBook > CAS DataBase List > METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Product Name
METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
CAS No.
66171-50-4
Chemical Name
METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
Synonyms
Nicorandil Impurity P;METHYL 6-HYDROXYNICOTINATE;Methyl6-hydroxynicotinate98%;Methyl6-Hydroxynicotinate>Methyl 6-hydroxynicotinate 98%;6-Hydroxynicotinate Methyl ester;Methylpyridin-2-one-5-carboxylate;5-METHOXYCARBONYL-2(1H)-PYRIDINONE;6-HYDROXY-NICOTINIC ACID METHYL ESTER;methyl 6-oxo-1H-pyridine-3-carboxylate
CBNumber
CB0733629
Molecular Formula
C7H7NO3
Formula Weight
153.14
MOL File
66171-50-4.mol
More
Less

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Property

Melting point:
166-170°C
Boiling point:
342.4±42.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
9.99±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
InChI
InChI=1S/C7H7NO3/c1-11-7(10)5-2-3-6(9)8-4-5/h2-4H,1H3,(H,8,9)
InChIKey
JTVVPKLHKMKWNN-UHFFFAOYSA-N
SMILES
C1NC(=O)C=CC=1C(OC)=O
CAS DataBase Reference
66171-50-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2727
Product name
Methyl 6-Hydroxynicotinate
Purity
>97.0%(GC)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
M2727
Product name
Methyl 6-Hydroxynicotinate
Purity
>97.0%(GC)
Packaging
5g
Price
$129
Updated
2025/07/31
TRC
Product number
M323478
Product name
Methyl 6-Hydroxynicotinate
Packaging
250mg
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-W005768
Product name
Methyl 6-Hydroxynicotinate
Purity
99.90%
Packaging
10g
Price
$74
Updated
2021/12/16
AK Scientific
Product number
W7719
Product name
6-Hydroxynicotinicacidmethylester
Packaging
1g
Price
$74
Updated
2021/12/16
More
Less

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 1428, 1982 DOI: 10.1021/ja00369a049
Organic Syntheses, Coll. Vol. 4, p. 532, 1963

Synthesis

67-56-1

5006-66-6

66171-50-4

General procedure for the synthesis of methyl 6-hydroxynicotinate from methanol and 6-hydroxynicotinic acid: first, 6-hydroxynicotinic acid (100 g, 719 mmol) was suspended in methanol (1 L). Subsequently, 18 M sulfuric acid (50 mL) was added and the reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the reaction mixture was cooled and sodium bicarbonate powder (45 g) was slowly added to partially neutralize the acidity. Next, most of the methanol was evaporated under reduced pressure. Water (1 L) was added to the residue and the pH was adjusted to 7 by careful addition of sodium bicarbonate solution. the suspension was extracted with dichloromethane (4 x 200 mL), the organic phases were combined and dried over anhydrous sodium sulfate. After removing the solvent under reduced pressure, the resulting solid was dried in a vacuum oven at 50 °C for 1.5 h to give 83 g (75% yield) of methyl 6-hydroxynicotinate as a white solid. Mass spectrum (electrospray ionization): 154.2 (MH+, C7H7NO3). 1H NMR (300 MHz, CDCl3): δ 3.88 (s, 3H), 6.59 (dd, 1H), 8.02 (dd, 1H), 8.21 (m, 1H), 13.19 (bs, 1H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6679 - 6703
[2] Patent: WO2012/52444, 2012, A1. Location in patent: Page/Page column 12
[3] Chemistry - A European Journal, 2009, vol. 15, # 24, p. 5950 - 5955
[4] Patent: WO2009/106885, 2009, A1. Location in patent: Page/Page column 296
[5] Organic and Biomolecular Chemistry, 2010, vol. 8, # 15, p. 3534 - 3542

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Suppliers

Americas 1 China 151 Europe 2 Germany 2 India 4 Japan 1 Ukraine 1 United Kingdom 7 United States 21 Global 190
Nantong Flying Pharmtech Co., Ltd.
Tel
13270692087
Fax
-
Email
2488110388@qq.com
Country
China
ProdList
32
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Shanghai Diluo Technology Co., LTD
Tel
18064769171 19526192903
Email
610451109@qq.com
Country
China
ProdList
171
Advantage
58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Record Tech (Shanghai) Co., LTD
Tel
13761627472
Fax
86-21-64965863
Email
183009664@qq.com
Country
China
ProdList
649
Advantage
62
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3764
Advantage
58
Tianjin Jinyuda Chemical Co., Ltd.
Tel
022-58013646 13011382049
Fax
022-23854368
Email
sales@jinyudachem.com
Country
China
ProdList
1930
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Hangzhou Trylead Chemical Technology Co.,LTD
Tel
0571-87086220 13516718938
Fax
0571-87012927
Email
zyf@trylead-chem.com
Country
China
ProdList
310
Advantage
64
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773
Fax
021-61486878
Email
sales@aspirebio.com
Country
China
ProdList
2880
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5253
Advantage
58
Shanghai Sainty Biotechnology Co., Ltd.
Tel
021-58957915 17721108391
Fax
QQ: 907522080
Email
907522080@qq.com
Country
China
ProdList
997
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
10410
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10109
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing BAM Biomedical Technology Co., Ltd.
Tel
18066080842 13952020641
Fax
025-58912720
Email
bamd@foxmail.com
Country
China
ProdList
759
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Chengdu Synguider Technology Co., Ltd.
Tel
400-086-3412 028-85062459
Fax
028-85062459
Email
synguider@163.com
Country
China
ProdList
3295
Advantage
55
Shanghai CR Corporation Limited
Tel
13062833949; 4006653949 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
9754
Advantage
58
Mirro Chemical Co.,Ltd.
Tel
0086-15313090952
Fax
0086-010-80236392
Country
China
ProdList
2355
Advantage
58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
15026866316
Email
180642609@qq.com
Country
China
ProdList
4967
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
13331045123
Fax
86-10-80339217
Email
2559355526@qq.com
Country
China
ProdList
14193
Advantage
58
More
Less

View Lastest Price from METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE manufacturers

Dideu Industries Group Limited
Product
METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 66171-50-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 66171-50-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Methyl 6-hydroxynicotinate 66171-50-4
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100kg
Release date
2019-12-20

66171-50-4, METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATERelated Search:

6-oxo-1,6-dihydropyridine-3-carboxylic acid hydrazide Ethyl 6-Hydroxyhexanoate 6-HYDROXYHEXANOIC ACID METHYL ESTER 6-HYDROXYNICOTINIC ACID ETHYL ESTER 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER Methyl 6-bromonicotinate METHYL 6-FORMYLNICOTINATE methyl 6-chloropyrimidine-4-carboxylate Methyl 6-bromoisoquinoline-1-carboxylate Methyl 6-bromohexanoate Methyl 6-chloronicotinate 6-CHLORO-2-PICOLINIC ACID METHYL ESTER METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE methyl 6-methylpyridine-2-carboxylate 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-bromo-2-naphthoate 6-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 2-Chloro-6-pyrazinecarboxylic acid methyl ester

  • Methyl6-hydroxynicotinate98%
  • METHYL 6-HYDROXYNICOTINATE
  • METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
  • METHYL 6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXYLATE
  • 6-HYDROXY-NICOTINIC ACID METHYL ESTER
  • Methylpyridin-2-one-5-carboxylate
  • 6-Oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester
  • Methyl 6-hydroxynicotinate 98%
  • 3-Pyridinecarboxylicacid,1,6-dihydro-6-oxo-,methylester(9CI)
  • 2-Oxo-1,2-dihydropyridine-5-carboxylic acid methyl ester
  • 6-keto-1H-pyridine-3-carboxylic acid methyl ester
  • methyl 6-oxo-1H-pyridine-3-carboxylate
  • Methyl 6-hydroxypyridine-3-carboxylate, Methyl 1,6-dihydro-6-oxopyridine-3-carboxylate
  • 3-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-, Methyl ester
  • 5-METHOXYCARBONYL-2(1H)-PYRIDINONE
  • Methyl 6-hydroxypyridine-3-carboxylate
  • Nicorandil P (Methyl 6-hydroxynicotinate)
  • Methyl6-Hydroxynicotinate&gt
  • Nicorandil Impurity P
  • 6-Hydroxy-3-pyridinecarboxylic Acid Methyl Ester
  • Methyl 6-Hydroxy-3-pyridinecarboxylate
  • METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE ISO 9001：2015 REACH
  • Methyl 1,6-dihydro-6-oxo-3-pyridinecarboxylate
  • 6-Hydroxynicotinate Methyl ester
  • 66171-50-4
  • CARBOXYLICESTER
  • blocks
  • Carboxes
  • Pyridines
  • Esters