1-Bromo-3-fluoro-5-nitrobenzene
- Product Name
- 1-Bromo-3-fluoro-5-nitrobenzene
- CAS No.
- 7087-65-2
- Chemical Name
- 1-Bromo-3-fluoro-5-nitrobenzene
- Synonyms
- 3-Bromo-5-fluoroaniline;1-Bromo-3-fluoro-5-nitrobenzene;5-AMINO-1-BROMO-3-FLUOROBENZENE;3-Bromo-5-fluoronitrobenzene 97%;Benzene, 1-bromo-3-fluoro-5-nitro-;1-Bromo-3-fluoro-5-nitrobenzene,98%;1-Bromo-3-fluoro-5-nitrobenzene, 97%;1-Bromo-3-fluoro-5-nitrobenzene ISO 9001：2015 REACH
- CBNumber
- CB0775539
- Molecular Formula
- C6H3BrFNO2
- Formula Weight
- 220
- MOL File
- 7087-65-2.mol
1-Bromo-3-fluoro-5-nitrobenzene Property
- Boiling point:
- 247.2±20.0 °C(Predicted)
- Density
- 1.808±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- color
- Yellow
- CAS DataBase Reference
- 7087-65-2
Safety
- RIDADR
- UN2810
- HazardClass
- 6.1
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B688643
- Product name
- 1-Bromo-3-fluoro-5-nitrobenzene
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 4654-B-Y3
- Product name
- 3-Bromo-5-fluoronitrobenzene
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 074506
- Product name
- 1-Bromo-3-fluoro-5-nitrobenzene
- Purity
- 95+%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- CS-W007693
- Product name
- 1-Bromo-3-fluoro-5-nitrobenzene
- Purity
- 98.18%
- Packaging
- 5g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 074506
- Product name
- 1-Bromo-3-fluoro-5-nitrobenzene
- Purity
- 95+%
- Packaging
- 5g
- Price
- $51
- Updated
- 2021/12/16
1-Bromo-3-fluoro-5-nitrobenzene Chemical Properties,Usage,Production
Synthesis
10472-88-5
7087-65-2
General procedure for the synthesis of 1-bromo-3-fluoro-5-nitrobenzene from 2-bromo-4-fluoro-6-nitroaniline: To a solution of 2-bromo-4-fluoro-6-nitroaniline (702 mg, 3 mmol) in ethanol (3 mL) was added 6 mL of 60% sulphuric acid at 0 °C, followed by the slow addition of sodium nitrite (414 mg, 6 mmol) in batches. After addition, stirring was continued for 1 hour while maintaining the reaction temperature at 0-5 °C. Subsequently, ferrous sulfate heptahydrate (4.38 g, 6 mmol) was added and the resulting mixture was continued to be stirred for 3 hours. After completion of the reaction, the mixture was concentrated, water was added and the aqueous phase was extracted with dichloromethane (20 mL x 3). The organic layers were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography (TLC) with the eluent dichloromethane/methanol = 60/1 to afford the target product 1-bromo-3-fluoro-5-nitrobenzene (yellow solid, 448 mg, 68% yield).
References
[1] Patent: WO2016/161145, 2016, A1. Location in patent: Paragraph 00704
[2] Journal of Antibiotics, 1994, vol. 47, # 12, p. 1456 - 1465
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 23, p. 3397 - 3402
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 11, p. 3243 - 3247
1-Bromo-3-fluoro-5-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-3-fluoro-5-nitrobenzene manufacturers
- Product
- 1-Bromo-3-fluoro-5-nitrobenzene 7087-65-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 2-Bromo-4-methylbenzoic acid 7087-65-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09