DBCO-PEG1-amine

Product Name: DBCO-PEG1-amine
CAS No.: 2364591-79-5
Chemical Name: DBCO-PEG1-amine
Synonyms: DBCO-PEG1-amine;DBCO-PEG1-NH2 TFA
CBNumber: CB08054694
Molecular Formula: C23H25N3O3
Formula Weight: 391.46
MOL File: 2364591-79-5.mol

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DBCO-PEG1-amine Property

Boiling point:: 730.9±60.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 15.15±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24344
Product name: DBCO-PEG1-amineTFAsalt
Purity: 98%
Packaging: 100mg
Price: $560
Updated: 2021/12/16

BroadPharm

Product number: BP-24344
Product name: DBCO-PEG1-amineTFAsalt
Purity: 98%
Packaging: 250mg
Price: $890
Updated: 2021/12/16

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DBCO-PEG1-amine Chemical Properties,Usage,Production

Description

DBCO-PEG1-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG1-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG1-amine Suppliers

China 14 United States 2 Global 16

Hangzhou J&H Chemical Co., Ltd.

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Xianning Shen Lan Biomedical Research and Development Co., Ltd.

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2364591-79-5, DBCO-PEG1-amineRelated Search:

5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester DBCO-PEG3-CH2CO-NHS DBCO-PEG4-amine DBCO-PEG4-SE DBCO-NHS Ester DBCO-PEG2-NH-Boc Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester DBCO-PEG4-DBCO DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS DBCO-PEG3-acid Azadibenzocyclooctyne-Biotin conjugate 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester DBCO-NH-(CH2)4COOH DBCO-PEG3-amine DBCO-NH-Boc

DBCO-PEG1-amine

DBCO-PEG1-NH2 TFA

2364591-79-5