DBCO-PEG4-DBCO
- Product Name
- DBCO-PEG4-DBCO
- CAS No.
- 2182601-68-7
- Chemical Name
- DBCO-PEG4-DBCO
- Synonyms
- DBCO-PEG4-DBCO;Bis-DBCO-NHCO-PEG4;DBCO-NHCO-PEG4-CONH-DBCO;4,7,10,13-Tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-
- CBNumber
- CB43339239
- Molecular Formula
- C48H50N4O8
- Formula Weight
- 810.93
- MOL File
- 2182601-68-7.mol
DBCO-PEG4-DBCO Property
- Boiling point:
- 1104.6±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, sealed storage, away from moisture
- form
- Solid
- pka
- 14.84±0.46(Predicted)
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- BP-23772
- Product name
- DBCO-PEG4-DBCO
- Purity
- 98%
- Packaging
- 100mg
- Price
- $540
- Updated
- 2021/12/16
DBCO-PEG4-DBCO Chemical Properties,Usage,Production
Description
DBCO-PEG4-DBCO is a homobifunctional PEG linker containing two DBCO groups and a hydrophilic PEG spacer arm. DBCO will react with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. The hydrophilic PEG spacer arm can increase water solubility and membrane permability.
Uses
DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
Cleavable Linker; PEGs
References
[1] Adam TIBBLES, et al. Engineered O-glycosylation in recombinant polypeptides via heterologous glycosylation sites. WO2019122234A1.
DBCO-PEG4-DBCO Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG4-DBCO Suppliers
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View Lastest Price from DBCO-PEG4-DBCO manufacturers
- Product
- DBCO-PEG4-DBCO 2182601-68-7
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- >99.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-20