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DBCO-PEG4-amine

Product Name
DBCO-PEG4-amine
CAS No.
1840886-10-3
Chemical Name
DBCO-PEG4-amine
Synonyms
DBCO-CONH-PEG4-amine;DBCO-PEG4-amine TFA salt;DBCO-PEG2-amine TFA salt;Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-;N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
CBNumber
CB14849428
Molecular Formula
C29H37N3O6
Formula Weight
523.63
MOL File
1840886-10-3.mol
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DBCO-PEG4-amine Property

Boiling point:
784.1±60.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
pka
15.14±0.46(Predicted)
form 
Viscous Liquid
color 
Light yellow to yellow
InChI
InChI=1S/C29H37N3O6/c30-13-15-35-17-19-37-21-22-38-20-18-36-16-14-31-28(33)11-12-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)
InChIKey
NFJQULPXXATMFO-UHFFFAOYSA-N
SMILES
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23958
Product name
DBCO-PEG4-amineTFAsalt
Purity
98%
Packaging
50mg
Price
$280
Updated
2021/12/16
BroadPharm
Product number
BP-23958
Product name
DBCO-PEG4-amineTFAsalt
Purity
98%
Packaging
100mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0107922
Product name
DBCO-PEG4-amine
Packaging
50mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0107922
Product name
DBCO-PEG4-amine
Packaging
100mg
Price
$1500
Updated
2021/12/16
BroadPharm
Product number
BP-23958
Product name
DBCO-PEG4-amineTFAsalt
Purity
98%
Packaging
500mg
Price
$1650
Updated
2021/12/16
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DBCO-PEG4-amine Chemical Properties,Usage,Production

Description

DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.

Biological Activity

DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

DBCO-PEG4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG4-amine Suppliers

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0431-0431-80514535 19917294565
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United States
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China
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China
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China
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sales@torreybio.com
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China
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China
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View Lastest Price from DBCO-PEG4-amine manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-PEG4-amine 1840886-10-3
Price
US $0.00/mg
Min. Order
50mg
Purity
>99.00%
Supply Ability
250
Release date
2024-03-20

1840886-10-3, DBCO-PEG4-amineRelated Search:


  • DBCO-PEG2-amine TFA salt
  • DBCO-PEG4-amine TFA salt
  • Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-
  • N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
  • DBCO-CONH-PEG4-amine
  • 1840886-10-3
  • Cleavable

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