DBCO-NH-Boc

Product Name: DBCO-NH-Boc
CAS No.: 1539290-74-8
Chemical Name: DBCO-NH-Boc
Synonyms: DBCO-NH-Boc;DBDBCO-NH-Boc;Carbamic acid, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-, 1,1-dimethylethyl ester;Carbamic acid,N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-, 1,1-dimethylethyl ester (ACI)
CBNumber: CB94849570
Molecular Formula: C23H24N2O3
Formula Weight: 376.45
MOL File: 1539290-74-8.mol

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DBCO-NH-Boc Property

Boiling point:: 622.0±55.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in DMSO, DCM, DMF
pka: 12.25±0.46(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24094
Product name: DBCO-NH-Boc
Purity: 98%
Packaging: 250mg
Price: $540
Updated: 2021/12/16

BroadPharm

Product number: BP-24094
Product name: DBCO-NH-Boc
Purity: 98%
Packaging: 500mg
Price: $780
Updated: 2021/12/16

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DBCO-NH-Boc Chemical Properties,Usage,Production

Description

DBCO-NH-Boc is a click chemistry reagent with a DBCO group. DBCO can undergo copper-free Click Chemistry reactions with azides.

Uses

DBCO-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-NH-Boc Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-NH-Boc Suppliers

China 25 United States 4 Global 29

Shanghai Send Pharmaceutical Technology Co., Ltd.

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1539290-74-8, DBCO-NH-BocRelated Search:

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DBCO-NH-Boc

Carbamic acid, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-, 1,1-dimethylethyl ester

DBDBCO-NH-Boc

Carbamic acid,N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-, 1,1-dimethylethyl ester (ACI)

1539290-74-8