(S)-1-Boc-3-hydroxymethyl-piperazine

Product Name: (S)-1-Boc-3-hydroxymethyl-piperazine
CAS No.: 314741-40-7
Chemical Name: (S)-1-Boc-3-hydroxymethyl-piperazine
Synonyms: tert-butyl (S)-3-(hydroxymethyl)piperazine-1-carboxylate;H57160;TL8002412;NSILYQWHARROMG-QMMMGPOBSA-N;(S)-4-N-Boc-2-hydroxyMeth...;(3S)-3-(Hydroxymethyl)piperazine;(S)-1-Boc-3-(hyroxyMethyl)piperazine;(S)-1-Boc-3-hydroxymethyl-piperazine;(S)-4-Boc-2-(Hydroxymethyl)piperazine;(3S)-1-Boc-3-(hydroxyMethyl)-piperazine
CBNumber: CB0947688
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: 314741-40-7.mol

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(S)-1-Boc-3-hydroxymethyl-piperazine Property

Boiling point:: 322.9±22.0 °C(Predicted)
Density: 1.085±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 14.97±0.10(Predicted)
CAS DataBase Reference: 314741-40-7

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H320Causes eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B600450
Product name: (S)-1-Boc-3-hydroxymethyl-piperazine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151259
Product name: (S)-4-N-Boc-2-hydroxymethyl-piperazine
Packaging: 100mg
Price: $51
Updated: 2021/12/16

ChemScene

Product number: CS-D0660
Product name: (S)-1-Boc-3-hydroxymethyl-piperazine
Purity: >98.0%
Packaging: 1g
Price: $54
Updated: 2021/12/16

Activate Scientific

Product number: AS3142
Product name: (S)-1-Boc-(3-hydroxymethyl)piperazine
Purity: 98% ee
Packaging: 1g
Price: $91
Updated: 2021/12/16

ChemScene

Product number: CS-D0660
Product name: (S)-1-Boc-3-hydroxymethyl-piperazine
Purity: >98.0%
Packaging: 5g
Price: $155
Updated: 2021/12/16

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(S)-1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Usage,Production

Definition

(S)-1-Boc-3-hydroxymethyl-piperazine is also known as (S)-4-N-Boc-2-(hydroxymethyl)piperazine or (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate.

Uses

(S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.

Synthesis

To synthesize (S)-1-Boc-3-hydroxymethyl-piperazine, a stirred suspension of (S)-piperazine-l,3-dicarboxylic acid l-tert-buty ester (5.00 g, 21.7 mmol) in THF (40 mL) was prepared. Slowly, 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added to the suspension. The reaction mixture was heated to 90 ℃ and stirred under reflux for 2 h. Before further proceeding, the mixture was removed from heat and an additional 1.5 equivalents of 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added. The reaction was then reheated and stirred under reflux for 2 h. Subsequently, the reaction mixture was cooled to 0 ℃ and quenched by slowly adding methanol. The resulting mixture was concentrated under reduced pressure, yielding a white solid. This solid was dissolved in THF (30 mL) and cooled to 0 ℃. Slowly, a 2.0 M solution of lithium aluminum hydride (LiAlH4) in THF (27 mL, 54.0 mmol) was added. The reaction was heated to 90 ℃ and stirred under reflux for 2 h. Another portion of 2.0 M LiAlH4 was added, and the reaction mixture was stirred under reflux for 4 hours, followed by overnight stirring at RT. The reaction mixture was then cooled to 0 ℃ and quenched by slowly adding 1.0 M aqueous sodium hydroxide (NaOH) solution until the exothermic reaction subsided. The product (S)-1-Boc-3-hydroxymethyl-piperazine was obtained after purification.

(S)-1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-3-hydroxymethyl-piperazine Suppliers

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View Lastest Price from (S)-1-Boc-3-hydroxymethyl-piperazine manufacturers

Career Henan Chemical Co

Product: (S)-4-N-Boc-2-(hydroxymethyl)piperazine 314741-40-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

314741-40-7, (S)-1-Boc-3-hydroxymethyl-piperazineRelated Search:

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI) (S)-1-Boc-3-(hyroxymethyl)piperidine 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-2-(hydroxymethyl)piperazine (S)-1-Boc-2-Hydroxymethyl-piperazine (R)-1-N-Boc-2-(hydroxymethyl)piperazine (R)-1-BOC-3-(Hydroxymethyl)piperazine (S)-1-Boc-3-hydroxymethyl-piperazine (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID (S)-1,4-BIS(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID

(S)-1-Boc-3-hydroxymethyl-piperazine

(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate

(S)-4-Boc-2-(Hydroxymethyl)piperazine

H57160

1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3S)-

(S)-4-N-Boc-2-hydroxyMeth...

(S)-1-Boc-3-(hyroxyMethyl)piperazine

tert-butyl (3S)-3-(hydroxyMethyl)piperazine-1-carboxylate

(3S)-1-Boc-3-(hydroxyMethyl)-piperazine

tert-butyl (S)-3-(hydroxymethyl)piperazine-1-carboxylate

(3S)-3-(Hydroxymethyl)piperazine

1,1-Dimethylethyl (3S)-3-(hydroxymethyl)-1-piperazinecarboxylate

NSILYQWHARROMG-QMMMGPOBSA-N

TL8002412

(3S)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester

314741-40-7

Piperaizine