ChemicalBook > CAS DataBase List > 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID

2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID

Product Name
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
CAS No.
302964-02-9
Chemical Name
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
Synonyms
2-Boc-aminothiazole-5-carboxylic acid;2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9;2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%;2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...;5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid
CBNumber
CB11119481
Molecular Formula
C9H12N2O4S
Formula Weight
244.27
MOL File
302964-02-9.mol
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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Property

Melting point:
220-222°(dec)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder to crystal
pka
5.53±0.70(Predicted)
color 
White to Almost white
CAS DataBase Reference
302964-02-9
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Safety

Hazard Codes 
Xi
Risk Statements 
43-36/37/38
Safety Statements 
36/37-36-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00310
Product name
2-(N-BOC)-Aminothiazole-5-carboxylic acid
Packaging
1g
Price
$185
Updated
2025/07/31
TCI Chemical
Product number
B4552
Product name
2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$463
Updated
2025/07/31
TCI Chemical
Product number
B4552
Product name
2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$154
Updated
2025/07/31
TRC
Product number
B693690
Product name
2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Packaging
1g
Price
$125
Updated
2021/12/16
AK Scientific
Product number
B303
Product name
2-(N-BOC)-Aminothiazole-5-carboxylic acid
Packaging
1g
Price
$41
Updated
2021/12/16
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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

A reactant used in the preparation of 2-aminocarboxamidothiazoles as inhibitors of Src-family kinase.

Synthesis

302964-01-8

302964-02-9

General procedure for the synthesis of 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid from ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate: To a vigorously stirred suspension of ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate (4.2 g, 15 mmol) in methanol (11 mL) was slowly added an aqueous 2 M NaOH solution (22 mL, 44.0 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under vacuum by rotary evaporator to remove methanol. The pH was adjusted to 1-2 by adding aqueous 6 N HCl dropwise to the residual aqueous suspension. the mixture was stirred for 1 h, during which time it was occasionally sonicated to promote precipitation. The resulting white solid was collected by filtration, washed thoroughly with deionized water and dried in a vacuum drying oven to afford 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid (3.7 g, 100% yield). Mass spectrometry analysis showed (M + H-Boc)+ = 145.

References

[1] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 109
[2] Patent: CN106674150, 2017, A. Location in patent: Paragraph 0022-0026
[3] Patent: US2004/54186, 2004, A1. Location in patent: Page 23
[4] Synthetic Communications, 2017, vol. 47, # 17, p. 1610 - 1621
[5] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1621 - 1628

2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Suppliers

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View Lastest Price from 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 302964-02-9
Price
US $150.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-07-30

302964-02-9, 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Related Search:

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  • 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid
  • 2-Boc-aminothiazole-5-carboxylic acid
  • 2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid
  • 5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
  • 2-(<i>tert</i>-Butoxycarbonylamino)thiazole-5-carboxylic Acid
  • 2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%
  • 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...
  • 2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9
  • 302964-02-9
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