2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
- Product Name
- 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 302964-02-9
- Chemical Name
- 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- 2-Boc-aminothiazole-5-carboxylic acid;2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9;2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%;2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...;5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid
- CBNumber
- CB11119481
- Molecular Formula
- C9H12N2O4S
- Formula Weight
- 244.27
- MOL File
- 302964-02-9.mol
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 220-222°(dec)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 5.53±0.70(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 302964-02-9
Safety
- Hazard Codes
- Xi
- Risk Statements
- 43-36/37/38
- Safety Statements
- 36/37-36-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- SYX00310
- Product name
- 2-(N-BOC)-Aminothiazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- B4552
- Product name
- 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $463
- Updated
- 2025/07/31
- Product number
- B4552
- Product name
- 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $154
- Updated
- 2025/07/31
- Product number
- B693690
- Product name
- 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- B303
- Product name
- 2-(N-BOC)-Aminothiazole-5-carboxylic acid
- Packaging
- 10g
- Price
- $161
- Updated
- 2021/12/16
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
A reactant used in the preparation of 2-aminocarboxamidothiazoles as inhibitors of Src-family kinase.
Synthesis
302964-01-8
302964-02-9
General procedure for the synthesis of 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid from ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate: To a vigorously stirred suspension of ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate (4.2 g, 15 mmol) in methanol (11 mL) was slowly added an aqueous 2 M NaOH solution (22 mL, 44.0 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under vacuum by rotary evaporator to remove methanol. The pH was adjusted to 1-2 by adding aqueous 6 N HCl dropwise to the residual aqueous suspension. the mixture was stirred for 1 h, during which time it was occasionally sonicated to promote precipitation. The resulting white solid was collected by filtration, washed thoroughly with deionized water and dried in a vacuum drying oven to afford 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid (3.7 g, 100% yield). Mass spectrometry analysis showed (M + H-Boc)+ = 145.
References
[1] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 109
[2] Patent: CN106674150, 2017, A. Location in patent: Paragraph 0022-0026
[3] Patent: US2004/54186, 2004, A1. Location in patent: Page 23
[4] Synthetic Communications, 2017, vol. 47, # 17, p. 1610 - 1621
[5] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1621 - 1628
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 302964-02-9
- Price
- US $150.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-30