ChemicalBook > CAS DataBase List > 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE

Product Name
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
CAS No.
4316-98-7
Chemical Name
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
Synonyms
6-Chloropyrimidine-4,5-diamine;100063;NSC 36907;4,5-DiaMino-6-chloropyriMidine;6-Chloro-4,5-diaminopyrimidine;6-Chloro-4,5-pyrimidinediamine;5 6-DIAMINO-4-CHLOROPYRIMIDINE;4-CHLORO-5,6-DIAMINOPYRIMIDINE;4-ChloropyriMidine-5,6-diaMine;4,5-Pyrimidinediamine, 6-chloro-
CBNumber
CB1131244
Molecular Formula
C4H5ClN4
Formula Weight
144.56
MOL File
4316-98-7.mol
More
Less

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Property

Melting point:
252 °C (decomp)
Boiling point:
336.7±37.0 °C(Predicted)
Density 
1.565
Flash point:
157℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
powder to crystal
pka
2.39±0.10(Predicted)
color 
White to Amber to Dark green
λmax
305nm(lit.)
Stability:
Hygroscopic
InChI
InChI=1S/C4H5ClN4/c5-3-2(6)4(7)9-1-8-3/h1H,6H2,(H2,7,8,9)
InChIKey
VNSFICAUILKARD-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C(N)C(N)=N1
CAS DataBase Reference
4316-98-7
EPA Substance Registry System
4,5-Pyrimidinediamine, 6-chloro- (4316-98-7)
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C3433
Product name
6-Chloropyrimidine-4,5-diamine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$89
Updated
2025/07/31
TRC
Product number
D416275
Product name
4,5-Diamino-6-chloropyrimidine
Packaging
2.5g
Price
$1210
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013399
Product name
5,6-DIAMINO-4-CHLOROPYRIMIDINE
Purity
95.00%
Packaging
2.5G
Price
$2035
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21470
Product name
4,5-Diamino-6-chloropyrimidine
Packaging
1g
Price
$199.5
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-8R
Product name
6-Chloropyrimidine-4,5-diamine
Purity
95%
Packaging
5G
Price
$298
Updated
2021/12/16
More
Less

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

4-Amino-6-chloropyrimidin-5-ylamine is a chlorinated diaminopyrimidine used in the preparation of various bioactive choloropurine derivatives.

Synthesis

5413-85-4

4316-98-7

Step 1: 4,6-Dichloropyrimidin-5-amine (1.64 g, 10 mmol) was suspended in 5 mL of concentrated hydrochloric acid. The suspension was transferred to a sealed tube, ammonia solution was added and the reaction was stirred at 100 °C overnight. Upon completion of the reaction, the solid product was collected by filtration and dried under vacuum to afford the target compound 6-chloropyrimidine-4,5-diamine as a yellow solid (1.2 g, 83% yield).LC-MS analysis showed m/z 145 ([M+H]+).

References

[1] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 115-116
[2] Patent: WO2008/75110, 2008, A1. Location in patent: Page/Page column 116
[3] Patent: WO2007/125315, 2007, A2. Location in patent: Page/Page column 115
[4] Patent: WO2007/125325, 2007, A1. Location in patent: Page/Page column 92-93
[5] Organic Process Research and Development, 2011, vol. 15, # 4, p. 841 - 854

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide 4,6-Dihydroxypyrimidine N,N-Diisopropylethylamine Nickel Trifluoroacetic acid Phosphorus oxitrichloride

Preparation Products

More
Less

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Suppliers

Americas 1 Canada 1 China 132 Europe 2 Germany 2 India 3 Japan 1 The Netherlands 1 United Kingdom 1 United States 16 Global 160
Specs
Tel
--
Fax
--
Email
info@specs.net
Country
The Netherlands
ProdList
6833
Advantage
70
More
Less

View Lastest Price from 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE manufacturers

Jiangsu Liyang Kunlun Biological Technology Co., Ltd.
Product
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
Price
US $0.00/kg
Min. Order
1000kg
Purity
0.99
Supply Ability
20 tons
Release date
2025-03-18
Shaanxi Dideu Medichem Co. Ltd
Product
4-Amino-6-chloropyrimidin-5-ylamine 4316-98-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

4316-98-7, 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINERelated Search:

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-Chloro-2,6-diaminopyrimidine 2,6-Diamino-4-chloropyrimidine 1-oxide 4,5-Diaminopyrimidine IFLAB-BB F2124-0139 IFLAB-BB F2124-0138 6-CHLORO-5-NITROPYRIMIDINE-2,4-DIAMINE 4-CHLORO-6-MORPHOLIN-4-YL-PYRIMIDIN-5-YLAMINE 6-CHLORO-N4,N4-DIMETHYL-PYRIMIDINE-4,5-DIAMINE IFLAB-BB F2124-0125 4-CHLORO-6-(4-METHYL-1-PIPERAZINYL)-5-NITROPYRIMIDINE N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-CHLORO-6-PIPERIDIN-1-YL-PYRIMIDIN-5-YLAMINE N4-benzyl-6-chloropyrimidine-4,5-diamine 4-CHLORO-5-NITRO-6-(1-PYRROLIDINYL)PYRIMIDINE N-benzyl-6-chloro-5-nitro-4-pyrimidinamine

  • 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
  • 4-CHLORO-5,6-DIAMINOPYRIMIDINE
  • 5 6-DIAMINO-4-CHLOROPYRIMIDINE
  • 4-Amino-6-chloropyrimidin-5-ylamine ,97%
  • 6-Chloro-4,5-pyrimidinediamine
  • 6-Chloro-4,5-diaminopyrimidine
  • 4,5-Pyrimidinediamine, 6-chloro- (9CI)
  • N-(1-phenylpropan-2-yl)-4,5-dihydrooxazol-2-amine
  • 100063
  • 6-Chloropyrimidine-4,5-diamine
  • 4,5-DiaMino-6-chloropyriMidine
  • 4-ChloropyriMidine-5,6-diaMine
  • NSC 36907
  • 4,5-Pyrimidinediamine, 6-chloro-
  • 4316-98-7
  • Heterocycle-Pyrimidine series
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • PYRIMIDINE