ChemicalBook > CAS DataBase List > 6-Chloropicolinic acid

6-Chloropicolinic acid

Product Name: 6-Chloropicolinic acid
CAS No.: 4684-94-0
Chemical Name: 6-Chloropicolinic acid
Synonyms: 6-CPA;2-CHLORO-6-PYRIDINECARBOXYLIC ACID;6-CHLOROPIC;6-Chloro-2-pic;6-chloropicolinic;OTAVA-BB BB5110090024;nitrapyrin metabolite;6-chloro-picolinicaci;Farnesane Impurity 43;6-CHLOROPICOLINIC ACID
CBNumber: CB1207534
Molecular Formula: C6H4ClNO2
Formula Weight: 157.55
MOL File: 4684-94-0.mol

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6-Chloropicolinic acid Property

Melting point:: 190-191°C
Boiling point:: 241.15°C (rough estimate)
Density: 1.3768 (rough estimate)
refractive index: 1.5870 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol
pka: 3.27±0.10(Predicted)
form: Crystalline Powder
color: White to cream to tan
Water Solubility: 3.40g/L(temperature not stated)
λmax: 294nm(EtOH)(lit.)
BRN: 115849
InChIKey: ZLKMOIHCHCMSFW-UHFFFAOYSA-N
CAS DataBase Reference: 4684-94-0(CAS DataBase Reference)
EPA Substance Registry System: 6-Chloropicolinic acid (4684-94-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 2
RTECS: TJ7535000
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H401Toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1896
Product name: 6-Chloro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: C1896
Product name: 6-Chloro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $120
Updated: 2025/07/31

TRC

Product number: C380615
Product name: 6-Chloropyridine-2-carboxylic acid
Packaging: 1g
Price: $50
Updated: 2021/12/16

TRC

Product number: C380615
Product name: 6-Chloropyridine-2-carboxylic acid
Packaging: 5g
Price: $80
Updated: 2021/12/16

TRC

Product number: C380615
Product name: 6-Chloropyridine-2-carboxylic acid
Packaging: 100g
Price: $250
Updated: 2021/12/16

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6-Chloropicolinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Plates

Uses

6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.

Synthesis

1929-82-4

4684-94-0

General procedure for the synthesis of 6-chloropyridine-2-carboxylic acid from 2-chloro-6-trichloromethylpyridine: 2-chloro-6-trichloromethylpyridine (115.5 g, 0.5 mol) and 98% concentrated sulfuric acid (60 g, 0.6 mol) were added sequentially to a 500 mL three-neck flask equipped with a thermometer. The reaction mixture was heated to 100 °C and maintained at this temperature for 8 hours. Upon completion of the reaction, the reaction solution was cooled to 60 °C and neutralized by slow dropwise addition of 27% ammonia until the pH reached 7. Subsequently, the reaction mixture was cooled to room temperature with continuous stirring to precipitate the solid. The white solid product was collected by diafiltration in 90% yield with a melting point of 192-193 °C.

References

[1] Patent: CN108530351, 2018, A. Location in patent: Paragraph 0011; 0026; 0027

6-Chloropicolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Chloropicolinic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 6-Chloropicolinic acid 4684-94-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Chloropicolinic acid 4684-94-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Chloropicolinic acid 4684-94-0
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-06

4684-94-0, 6-Chloropicolinic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate 2-Chloro-5-chloromethylpyridine 2-Chloro-3-cyanopyridine Quinolinic acid 2,5-PYRIDINEDICARBOXYLIC ACID Clopidol 6-Chloroimidazo[2,1-f]pyridazine ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 2-Amino-6-chloropyridine 2-Chloropyridine-5-sulfonyl chloride (6-Chloro-2-pyridinyl)methanol 5-CHLOROPICOLINIC ACID pyridinium Chlorochromate 2-Chloropyridine Picloram Clopyralid (2-hydroxyethyl)ammonium Tetrachloropyridine-2-carboxylic acid 6-CHLOROPYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER

OTAVA-BB BB5110090024

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6-CHLORO-2-PICOLINIC ACID

6-CHLOROPICOLINIC ACID

6-CHLOROPYRIDINE-2-CARBOXYLIC ACID

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2-Pyridinecarboxylicacid,6-chloro-

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6-Chloropyridine-2-carboxylic acid 97%

6-Chloropicolinic acid, 98$, CA-4246

6-Chloro-2-pic

6-Chloropicolinic Acid(WX614070)

6-CHLOROPIC

6-Chloropyridine-2-carboxylicacid,98%

nitrapyrin metabolite

6-Chloro-2-pyridinecarboxylic

6-chloro-2-pyridinecarboxylicaci

6-chloropicolinic

6-chloro-picolinicaci

6-CHLOROPYRIDINE-2-CARBOXYLIC ACID 96+%

6-CHLORO-2-PYRIDINECARBOXYLIC ACID / 6-CHLOROPICOLINIC ACID

6-CHLORO-2-CARBOXY-PYRIDINE

6-Chloro-2-pyridinecarboxylic Acid &gt

oropyridine-2-carboxyL

6-Chloropicolinic acid ISO 9001：2015 REACH

2-chloro-6-picolinic acid

C11495000 6-Chloro-2-picoliniCacid

Farnesane Impurity 43

4684-94-0

4864-94-0

684-94-0

C6H4ClN2O

C6H4CINO2

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Building Blocks

Picolinic acid series

Carboxylic Acids

Heterocycles

Pyridines, Pyrimidines, Purines and Pteredines

pharmacetical

Carboxylic Acids

Organic acids

blocks

Carboxes

Pyridines

Pyridine

pyridine derivative

4684-94-0