2-Chloropyridine-5-sulfonyl chloride
- Product Name
- 2-Chloropyridine-5-sulfonyl chloride
- CAS No.
- 6684-39-5
- Chemical Name
- 2-Chloropyridine-5-sulfonyl chloride
- Synonyms
- AURORA 16313;AKOS BBS-00006680;OTAVA-BB BB7110951371;2-Chloropyridine-5-sulfonyl;2-chloro-5-pyridinesulfonylchloride;6-Chloro-3-pyridinesulfonyl Chloride;2-Chloropyridine-5-sulphonylchloride;2-CHLOROPYRIDINE-5-SULFONYL CHLORIDE;2-chloro-5-pyridinesulphonyl chloride;3-Pyridinesulfonylchloride, 6-chloro-
- CBNumber
- CB1416705
- Molecular Formula
- C5H3Cl2NO2S
- Formula Weight
- 212.05
- MOL File
- 6684-39-5.mol
2-Chloropyridine-5-sulfonyl chloride Property
- Melting point:
- 51 °C
- Boiling point:
- 132 °C(Press: 8 Torr)
- Density
- 1.615±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -5.29±0.10(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C5H3Cl2NO2S/c6-5-2-1-4(3-8-5)11(7,9)10/h1-3H
- InChIKey
- QXZKKHONVQGXAK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC=C1S(Cl)(=O)=O
- CAS DataBase Reference
- 6684-39-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS010949
- Product name
- 6-chloro-pyridine-3-sulfonyl chloride
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $185
- Updated
- 2025/07/31
- Product number
- C380360
- Product name
- 6-Chloro-3-pyridinesulfonylChloride
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- J93582
- Product name
- 2-Chloropyridine-5-sulfonylchloride,tech.
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FC10590
- Product name
- 6-Chloropyridine-3-sulfonyl chloride
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FC10590
- Product name
- 6-Chloropyridine-3-sulfonyl chloride
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
2-Chloropyridine-5-sulfonyl chloride Chemical Properties,Usage,Production
Uses
6-Chloro-3-pyridinesulfonyl Chloride, is a heterocylic building block used for chemical synthesis. It is also an intermediate in the synthesis of 6-Aminopyridine-3-sulfonamide (A628835), that can be used as anticoccidial agents.
Synthesis
5350-93-6
6684-39-5
General procedure for the synthesis of 2-chloropyridine-5-sulfonyl chloride from 2-chloro-5-aminopyridine: 10 g (79.2 mmol) of 2-chloro-5-aminopyridine was dissolved in a mixture of concentrated hydrochloric acid (16 mL) and glacial acetic acid (89 mL), and cooled to 10 °C in an ice bath. 5.46 g (79.2 mmol) of sodium nitrite was added in batches and the reaction temperature was controlled to be below 15 °C. After stirring the reaction mixture for 1 hour, it was slowly added dropwise to a solution containing sulfur dioxide (carrier 27 mL), 2.77 g (16.2 mmol) of sulfur dioxide, copper(II) chloride dihydrate, and a solution consisting of acetic acid (59 mL) and water (11 mL), with the dropwise addition time being controlled to be between 5 and 10 minutes. The reaction mixture was gradually warmed to room temperature and subsequently poured into an ice-water mixture (300 mL) and stirring was continued for 15 minutes. The precipitate was isolated by filtration, washed with water (2 x 100 mL) and dried under reduced pressure to give 12.99 g of 2-chloropyridine-5-sulfonyl chloride. The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 7.62 (1H, d, J = 8.31 Hz), 8.26 (1H, dd, J = 8.56,2.69 Hz), 9.04 (1H, d, J = 2.69 Hz).
References
[1] Patent: US2008/39464, 2008, A1. Location in patent: Page/Page column 30-31
[2] Organic Process Research and Development, 2009, vol. 13, # 5, p. 875 - 879
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3947 - 3953
[4] Patent: WO2009/39328, 2009, A1. Location in patent: Page/Page column 54
[5] Patent: EP1144368, 2004, B1. Location in patent: Page 64
2-Chloropyridine-5-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloropyridine-5-sulfonyl chloride manufacturers
- Product
- 2-Chloropyridine-5-sulfonyl chloride 6684-39-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-02
- Product
- 2-Chloropyridine-5-sulfonyl chloride 6684-39-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24