ChemicalBook > CAS DataBase List > Ethisterone

Ethisterone

Product Name
Ethisterone
CAS No.
434-03-7
Chemical Name
Ethisterone
Synonyms
Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
CBNumber
CB1207877
Molecular Formula
C21H28O2
Formula Weight
312.45
MOL File
434-03-7.mol
More
Less

Ethisterone Property

Melting point:
263-269 °C (lit.)
Boiling point:
392.36°C (rough estimate)
alpha 
D23 +23.8° (dioxane); D25 -32.0° (pyridine)
Density 
1.0697 (rough estimate)
refractive index 
33 ° (C=1, Pyridine)
storage temp. 
room temp
solubility 
Soluble to 0.05 mg/mL (0.16 mM) in DMSO
pka
13.10±0.60(Predicted)
form 
Solid
color 
Light yellow to yellow
Water Solubility 
soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
Merck 
14,3741
BRN 
1889895
InChIKey
CHNXZKVNWQUJIB-CEGNMAFCSA-N
CAS DataBase Reference
434-03-7
NIST Chemistry Reference
Ethisterone(434-03-7)
More
Less

Safety

Hazard Codes 
Xn,T
Risk Statements 
40-48-61
Safety Statements 
22-24/25-45-53
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
TU5570250
HS Code 
29372390
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1001
Product name
Ethisterone
Purity
≥99% (HPLC)
Packaging
25g
Price
$252
Updated
2024/03/01
Alfa Aesar
Product number
J63580
Product name
Ethisterone, 98%
Packaging
5g
Price
$176
Updated
2024/03/01
Alfa Aesar
Product number
J63580
Product name
Ethisterone, 98%
Packaging
25g
Price
$382
Updated
2024/03/01
Cayman Chemical
Product number
22893
Product name
Ethisterone
Purity
≥95%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22893
Product name
Ethisterone
Purity
≥95%
Packaging
5g
Price
$93
Updated
2024/03/01
More
Less

Ethisterone Chemical Properties,Usage,Production

Description

Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.

Chemical Properties

Off-White Powder

Originator

Lutocyclin,Ciba

Uses

Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone

Uses

Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.

Definition

ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.

Manufacturing Process

0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.

Therapeutic Function

Progestin

General Description

Ethisterone is a?progestogen. It is a danazol derivative.

Biochem/physiol Actions

Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.

Ethisterone Preparation Products And Raw materials

Raw materials

Dehydroepiandrosterone

Preparation Products

More
Less

Ethisterone Suppliers

Americas 1 Australia 1 Belgium 1 Canada 3 China 228 Europe 3 Germany 11 India 32 Japan 1 Jordan 1 Poland 1 Slovakia 1 Slovenia 1 Switzerland 1 United Kingdom 15 United States 45 Uruguay 1 Venezuela 1 Global 348
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Olinax Inc.
Tel
--
Fax
--
Email
info@olinax.com
Country
United States
ProdList
404
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Fragmenta
Tel
--
Fax
--
Email
sales@fragmenta.com
Country
United States
ProdList
1068
Advantage
0
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Anantco
Tel
--
Fax
--
Country
United States
ProdList
13
Advantage
59
Lab Express
Tel
--
Fax
--
Email
sales@labexpress.com
Country
United States
ProdList
1577
Advantage
67
Steraloids Inc.
Tel
--
Fax
--
Email
sales@steraloids.com
Country
United States
ProdList
2357
Advantage
68
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Research Plus, Inc.
Tel
--
Fax
--
Email
respls@aol.com
Country
United States
ProdList
3674
Advantage
51
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from Ethisterone manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Ethisterone 434-03-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
Hebei Weibang Biotechnology Co., Ltd
Product
Ethisterone 434-03-7
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ethisterone 434-03-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-23

434-03-7, EthisteroneRelated Search:

Testosterone 4'-Hydroxyacetophenone Zearalenone Quinocetone Androstenedione CHLOROPHOSPHONAZO III 2'-Hydroxyacetophenone Clethodim Gestrinone Norgestrel 6-Methyl-5-hepten-2-one 19-NOR-4-ETHISTERONE DIMETHISTERONE Progesterone Acetylene Oracon 2-hydroxy methylene ethisterone 2-(hydroxymethyl)ethisterone

  • 4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
  • 4,17a-pregnen-17b-ol-20-yn-3-one
  • 4,17A-PREGNEN-17B-OL-20-YNE
  • 4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • ANHYDROHYDROXYPROGESTERONE
  • ANHYDROXYPROGESTERONE
  • 17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE
  • 17b-hydroxy-4,17a-pregnen-20-yn-3-one
  • (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • Ethisterone, 98%, a progestogen hormone being considered to treat prostate cancer
  • pregneninolo
  • 17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE
  • 17a-ethynyl-17b-hydroxy-4-androsten-3-one
  • 17A-ETHYNYLTESTOSTERONE
  • 17ALPHA-ETHYNYLTESTOSTERONE
  • 17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY
  • ETHISTERONE(RG)
  • Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • ETHISTERONE(RG)(CALL)
  • Ethisterone 0
  • (17α)-17-hydroxy-pregn-4-en-20-yn-3-one
  • ETHINYL TESTOSTERONE
  • ETHISTERONE
  • ETHYNYLTESTOSTERONE
  • ETHYNYLANDROSTENOLONE
  • (17-alpha)-pregn-4-en-20-yn-3-on
  • Gestoral
  • Lucorteum Oral
  • lucorteumoral
  • Lutidon Oral
  • lutidonoral
  • Lutocyclin
  • Lutocyclol
  • Lutocylol
  • Nalutoral
  • NSC-9565
  • Nugestoral
  • Ora-Lutin
  • Pranone
  • Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)-
  • Pregneninolone
  • Pregnin
  • Primolut C
  • primolutc
  • Prodoxan
  • Prodroxan
  • Produxan
  • Progestab
  • Progestin P
  • progestinp
  • Progestolets
  • Progestoral
  • Prolutol
  • Proluton C
  • 17-alpha-ethinyltestosterone
  • 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one