Ethyl 4-bromobenzoate Property

Melting point:

18 °C

Boiling point:

131 °C/14 mmHg (lit.)

Density 

1.403 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.544(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.403

Water Solubility 

Insoluble

Merck 

14,1408

BRN 

1867129

InChIKey

XZIAFENWXIQIKR-UHFFFAOYSA-N

CAS DataBase Reference

5798-75-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 4-bromo-, ethyl ester(5798-75-4)

EPA Substance Registry System

Benzoic acid, 4-bromo-, ethyl ester (5798-75-4)

Safety

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-51/53

Safety Statements 

24/25-61

RIDADR 

UN 3082 9 / PGIII

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29163990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

Ethyl 4-bromobenzoate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellow liquid

Uses

Ethyl 4-bromobenzoate undergoes reduction with potassium diisobutyl-t-butoxyaluminum hydride (PDBBA) at 0°C to yield aldehydes. Reaction of ethyl 4-bromobenzoate and substituted benzyl chloride with zinc dust and a Pd catalyst is reported.

Synthesis Reference(s)

Synthetic Communications, 22, p. 1851, 1992 DOI: 10.1080/00397919208021316
Synthesis, p. 191, 1983

General Description

Ethyl 4-bromobenzoate is an ester having electron-withdrawing substituent. It undergoes reduction with potassium diisobutyl-t-butoxyaluminum hydride (PDBBA) at 0°C to yield aldehydes. Reaction of ethyl 4-bromobenzoate and substituted benzyl chloride with zinc dust and a Pd catalyst is reported.