Brivanib alaninate

Product Name: Brivanib alaninate
CAS No.: 649735-63-7
Chemical Name: Brivanib alaninate
Synonyms: CS-362;Bms582664;Bms 582664;Neopterin-13C5;Unii-U2Y5ofn795;Brivanib alaninate;[14C]-Brivanib alaninate;Unii-U2Y5ofn795 USP/EP/BP;Brivanib alaninate BMS-540215;Brivanib alaninate(BMS-582664)
CBNumber: CB12497201
Molecular Formula: C22H24FN5O4
Formula Weight: 441.46
MOL File: 649735-63-7.mol

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Brivanib alaninate Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH
form: Yellow powder.
pka: 16.08±0.30(Predicted)
color: White to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26081
Product name: Brivanib Alaninate
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 26081
Product name: Brivanib Alaninate
Packaging: 50mg
Price: $926
Updated: 2024/03/01

Cayman Chemical

Product number: 26081
Product name: Brivanib Alaninate
Packaging: 10mg
Price: $209
Updated: 2024/03/01

Cayman Chemical

Product number: 26081
Product name: Brivanib Alaninate
Packaging: 25mg
Price: $492
Updated: 2024/03/01

TRC

Product number: B677640
Product name: BrivanibAlaninate
Packaging: 50mg
Price: $875
Updated: 2021/12/16

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Brivanib alaninate Chemical Properties,Usage,Production

Uses

BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.

Uses

A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.

Definition

ChEBI: Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib.

target

VEGFR2

Brivanib alaninate Preparation Products And Raw materials

Raw materials

Preparation Products

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Brivanib alaninate Suppliers

Canada 1 China 126 India 4 United Kingdom 3 United States 18 Global 152

LGM Pharma

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View Lastest Price from Brivanib alaninate manufacturers

Career Henan Chemical Co

Product: Unii-U2Y5ofn795 649735-63-7
Price: US $0.10/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 100kg; 1000kg
Release date: 2019-12-24

649735-63-7, Brivanib alaninateRelated Search:

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol CCT 137690 Tariquidar (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Torin 1 Telaprevir Avagacestat (BMS-708163) RO4929097 CUDC-101 AC480 (BMS-599626) AZD 1480 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AZD-8055 (+)-JQ1 Nintedanib Linifanib (ABT-869) Trifluoromethyl

BMS-582664;BMS 582664;BMS582664

CS-362

L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester

(2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aMinopropanoate

Brivanib alaninate BMS-540215

(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664)

Bms 582664

Bms582664

Brivanib alaninate

L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester

Unii-U2Y5ofn795

(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester

[14C]-Brivanib alaninate

(S)-(R)-1-((4-((5-Fluoro-2-methyl-1H-indol-6-yl)oxy)-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-y

Brivanib alaninate(BMS-582664)

Unii-U2Y5ofn795 USP/EP/BP

(R)-(S)-1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl 2-aminopropanoate

Neopterin-13C5

649735-63-7

C22H24FN5O4

Inhibitors

Anti-cancer & immunity

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals