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Gefitinib-d6

Product Name
Gefitinib-d6
CAS No.
1228664-49-0
Chemical Name
Gefitinib-d6
Synonyms
Gefitinib-d6;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CBNumber
CB12674404
Molecular Formula
C22H24ClFN4O3
Formula Weight
446.91
MOL File
1228664-49-0.mol
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Gefitinib-d6 Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22364
Product name
Gefitinib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
500μg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
22364
Product name
Gefitinib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
1mg
Price
$243
Updated
2024/03/01
TRC
Product number
G304008
Product name
Gefitinib-d6
Packaging
10mg
Price
$1540
Updated
2021/12/16
TRC
Product number
G304008
Product name
Gefitinib-d6
Packaging
25mg
Price
$3520
Updated
2021/12/16
AK Scientific
Product number
3663DG
Product name
Gefitinib-d6
Packaging
1mg
Price
$370
Updated
2021/12/16
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Gefitinib-d6 Chemical Properties,Usage,Production

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

Gefitinib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

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Gefitinib-d6 Suppliers

China 13 United States 4 Global 17
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19884
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

1228664-49-0, Gefitinib-d6Related Search:

4-(3-Chloropropyl)morpholine 4,4'-(propane-1,3-diyl)bismorpholine Gefitinib N-Oxide 4-Defluoro-4-hydroxy Gefitinib Gefitinib 3-Hydroxy-4-methoxybenzonitrile 3-Chloro-4-fluoroaniline 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 3,4-Dichloroaniline N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine Gefitinib 3,4-Difluoro Impurity HCl 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

  • Gefitinib-d6
  • Hexadeuterated gefitinib
  • [2H6]-Gefitinib
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
  • 1228664-49-0