ChemicalBook > CAS DataBase List > 2-Fluoro-4-iodoaniline

2-Fluoro-4-iodoaniline

Product Name
2-Fluoro-4-iodoaniline
CAS No.
29632-74-4
Chemical Name
2-Fluoro-4-iodoaniline
Synonyms
uoro-4-iodoaniL;2-Fluor-4-Iodanilin;2-fluo-4-iodoaniline;2-Fluoro-4-iodoanili;2-fluro-4-iodoaniline;2-FLUORO-4-IODOANILINE;4-iodo-2-fluoroaniline;2-Fluoro-4-idioaniline;4-iodo-o-fluoroaniline;2-FLORO 4-IODO ANILINE
CBNumber
CB1281329
Molecular Formula
C6H5FIN
Formula Weight
237.01
MOL File
29632-74-4.mol
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2-Fluoro-4-iodoaniline Property

Melting point:
55-57 °C (lit.)
Boiling point:
248.6±25.0 °C(Predicted)
Density 
2.008±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
2.41±0.10(Predicted)
form 
Powder
color 
Off-white to brown
Water Solubility 
insoluble
Sensitive 
Light Sensitive
BRN 
2081100
InChIKey
CUMTUBVTKOYYOU-UHFFFAOYSA-N
LogP
2.680 (est)
CAS DataBase Reference
29632-74-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-37/39-26/37/39
RIDADR 
PG3
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
IRRITANT-HARMFUL, LIGHT SENSITIVE
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0417
Product name
2-Fluoro-4-iodoaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
F0417
Product name
2-Fluoro-4-iodoaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$68
Updated
2025/07/31
TRC
Product number
F591985
Product name
2-Fluoro-4-iodoaniline
Packaging
25g
Price
$50
Updated
2021/12/16
TRC
Product number
F591985
Product name
2-Fluoro-4-iodoaniline
Packaging
50g
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
PC3759E
Product name
2-Fluoro-4-iodoaniline
Purity
98%
Packaging
25g
Price
$16
Updated
2021/12/16
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2-Fluoro-4-iodoaniline Chemical Properties,Usage,Production

Chemical Properties

off-white to brown powder

Uses

2-Fluoro-4-iodoaniline is widely used in the pharmaceutical, chemical and food industries as a fundamental building block to create a variety of important compounds.

General Description

The profiling of iodine-containing metabolites produced by the earthworm Eisenia veneta by exposing it to 2-fluoro-4-iodoaniline was carried out using high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS).

Synthesis

348-54-9

29632-74-4

The general procedure for the synthesis of 2-fluoro-4-iodoaniline from o-fluoroaniline is as follows: o-fluoroaniline (54 g, 486 mmol) was added to an aqueous solution (250 mL) of sodium bicarbonate (41 g, 486 mmol) with vigorous stirring. The suspension was heated to 60 °C in an oil bath and iodine (123 g, 486 mmol) was added in batches. After addition, the dark-colored mixture was continued to be stirred at 60°C for 3 hours. After completion of the reaction, it was cooled to room temperature and dichloromethane (300 mL) was added, followed by saturated sodium bisulfite solution (300 mL). The two-phase system was stirred vigorously for 10 minutes. The mixture was transferred to a 2L separatory funnel and the organic layer was separated. The aqueous layer was further extracted with dichloromethane (3 x 200 mL) and the combined organic phases were washed with brine (200 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under reduced pressure to give a black crystalline solid. Hexane (300 mL) was added to the solid and the mixture was heated to reflux. A hexane solution was poured from the black insoluble syrup. Upon cooling, the product crystallized from hexane as fine yellow needles. Final isolation afforded 65 g (274 mmol) of 2-fluoro-4-iodoaniline as a fine yellow solid in 56% yield with a melting point of 53°C. 1H NMR (400 MHz, CDCl3) δ 8.1 (t, J=8Hz, 1H), 7.4 (d, J=6Hz, 1H), 7.2 (d, J=6Hz, 1H).

References

[1] Journal of the Chemical Society. Perkin Transactions 2, 1999, # 3, p. 481 - 491
[2] Arzneimittel-Forschung/Drug Research, 1984, vol. 34, # 11 A, p. 1612 - 1624
[3] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2870 - 2873
[4] Patent: WO2004/41793, 2004, A1. Location in patent: Page 141
[5] Chemical Communications, 2014, vol. 50, # 17, p. 2136 - 2138

2-Fluoro-4-iodoaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-iodoaniline Suppliers

Americas 1 Belgium 1 Canada 1 China 366 Europe 5 France 1 Germany 4 India 10 Italy 1 Japan 2 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 42 USA 1 Global 451
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View Lastest Price from 2-Fluoro-4-iodoaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Fluoro-4-iodoaniline 29632-74-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Fluoro-4-iodoaniline 29632-74-4
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-05
Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoro-4-iodoaniline 29632-74-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

29632-74-4, 2-Fluoro-4-iodoanilineRelated Search:

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  • 2-FLORO 4-IODO ANILINE
  • Pioglitazone intermediate
  • 2-fluro-4-iodoaniline
  • 29632-74-4
  • 29632-47-4
  • C6H5FIN
  • FC6H3INH2
  • Nitrogen Compounds
  • Organic Building Blocks
  • C2 to C6
  • Amines
  • Building Blocks
  • Benzenes
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Fluorobenzene
  • Fluoro-Aromatics
  • Benzene series
  • Aniline
  • Miscellaneous
  • Anilines, Amides & Amines
  • Fluorine Compounds
  • Iodine Compounds
  • amine| alkyl Fluorine| alkyl Iodine
  • bc0001