ChemicalBook > CAS DataBase List > Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Product Name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS No.
1391728-01-0
Chemical Name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Synonyms
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite;O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite;2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite;Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester
CBNumber
CB13062620
Molecular Formula
C16H29N2O4P
Formula Weight
344.39
MOL File
1391728-01-0.mol
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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Property

Boiling point:
387.2±37.0 °C(Predicted)
pka
3.53±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-22317
Product name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity
Tech
Packaging
100mg
Price
$430
Updated
2021/12/16
BroadPharm
Product number
BP-22317
Product name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity
Tech
Packaging
250mg
Price
$750
Updated
2021/12/16
Apolloscientific
Product number
BIPG1737
Product name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Packaging
100mg
Price
$837
Updated
2021/12/16
BroadPharm
Product number
BP-22317
Product name
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity
Tech
Packaging
500mg
Price
$1125
Updated
2021/12/16
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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Properties,Usage,Production

Biological Activity

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Suppliers

China 12 United Kingdom 1 United States 2 Global 15
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88

1391728-01-0, Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramiditeRelated Search:

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  • O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite
  • Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester
  • 2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite
  • 1391728-01-0
  • C16H29N2O4P