ChemicalBook > CAS DataBase List > ERK Inhibitor

ERK Inhibitor

Product Name: ERK Inhibitor
CAS No.: 1049738-54-6
Chemical Name: ERK Inhibitor
Synonyms: ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber: CB13136749
Molecular Formula: C14H17ClN2O3S
Formula Weight: 328.81
MOL File: 1049738-54-6.mol

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ERK Inhibitor Property

storage temp.: +2C to +8C
solubility: DMSO: 2 mg/ml
form: Light yellow solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 328006-M
Product name: ERK Inhibitor
Purity: The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica
Packaging: 1 unit
Price: $133
Updated: 2025/07/31

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

AK Scientific

Product number: 9473CW
Product name: ErkInhibitor
Packaging: 5mg
Price: $228
Updated: 2021/12/16

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ERK Inhibitor Chemical Properties,Usage,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (K_D = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC₅₀ = 15-20 μM), A549 lung carcinoma cells (IC₅₀ = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

Uses

ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1].

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

IC 50

ERK2: 5 μM (Kd)

References

[1] Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95. DOI:10.1021/jm0501174

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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1049738-54-6, ERK InhibitorRelated Search:

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride

ERK-IN-4

1049738-54-6