ChemicalBook > CAS DataBase List > SR 0987

SR 0987

Product Name
SR 0987
CAS No.
303126-97-8
Chemical Name
SR 0987
Synonyms
SR 0987;SR0987 >=98% (HPLC);SR 0987;SR-0987;SR0987;303126-97-8;SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
CBNumber
CB13152747
Molecular Formula
C16H10ClF6NO2
Formula Weight
397.7
MOL File
303126-97-8.mol
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SR 0987 Property

Boiling point:
378.8±42.0 °C(Predicted)
Density 
1.525±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
pka
9.22±0.15(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19503
Product name
SR 0987
Purity
≥98%
Packaging
1mg
Price
$27
Updated
2024/03/01
Cayman Chemical
Product number
19503
Product name
SR 0987
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
19503
Product name
SR 0987
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
19503
Product name
SR 0987
Purity
≥98%
Packaging
25mg
Price
$236
Updated
2024/03/01
Tocris
Product number
5868
Product name
SR0987
Purity
≥98%(HPLC)
Packaging
50
Price
$704
Updated
2021/12/16
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SR 0987 Chemical Properties,Usage,Production

Description

SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.

Uses

SR 0987 is a RORγt agonist.

storage

Store at +4°C

References

1) Chang?et al.?(2016),?Synthetic RORγt Agonists Enhance Protective Immunity;?ACS Chem. Biol.?11?1012

SR 0987 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 0987 Suppliers

China 38 India 1 United Kingdom 1 United States 8 USA 1 Global 49
Shanghai YuanYe Biotechnology Co., Ltd.
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303126-97-8, SR 0987Related Search:

2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR9009 SR19881 SR-9243 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR27897 SR17018 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine SR8278 SR-4835 SR18662

  • SR 0987
  • 2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
  • 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
  • SR 0987;SR-0987;SR0987;303126-97-8
  • Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
  • SR0987 >=98% (HPLC)
  • SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor
  • 303126-97-8
  • C16H10ClF6NO2
  • API