ChemicalBook > CAS DataBase List > 4-Chlorophenylhydrazine hydrochloride

4-Chlorophenylhydrazine hydrochloride

Product Name
4-Chlorophenylhydrazine hydrochloride
CAS No.
1073-70-7
Chemical Name
4-Chlorophenylhydrazine hydrochloride
Synonyms
CHLOROPHENYLHYDRAZINE(4-) HCL;LABOTEST-BB LT01147712;P-CHLOROPHENYLHYDRAZINE HCL;P-Chloropheyl hydrazine HCl;4-CHLOROPHENYLHYDRAZINE HCL;p-Chlorphenylhydrazinhydrochlorid;4-chlorophenyl hydrazine, 98%min;hlorophenylhydrazine hydrochloride;Chlorphenylhydrazine hydrochloride;P-CHLOROPHENYLHYDRAZINE HYDROCHLORIDE
CBNumber
CB1330472
Molecular Formula
C6H8Cl2N2
Formula Weight
179.05
MOL File
1073-70-7.mol
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4-Chlorophenylhydrazine hydrochloride Property

Melting point:
216 °C (dec.)(lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
Crystalline Powder
color 
White to pink
Water Solubility 
Soluble in hot water, methanol.
BRN 
3596254
InChI
InChI=1S/C6H7ClN2.ClH/c7-5-1-3-6(9-8)4-2-5;/h1-4,9H,8H2;1H
InChIKey
YQVZREHUWCCHHX-UHFFFAOYSA-N
SMILES
N(C1=CC=C(Cl)C=C1)N.[H]Cl
CAS DataBase Reference
1073-70-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
36/37-36-26
RIDADR 
2811
WGK Germany 
3
Hazard Note 
Harmful/Irritant
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29280090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C65807
Product name
4-Chlorophenylhydrazine hydrochloride
Purity
98%
Packaging
5g
Price
$56.3
Updated
2025/07/31
Sigma-Aldrich
Product number
C65807
Product name
4-Chlorophenylhydrazine hydrochloride
Purity
98%
Packaging
25g
Price
$105
Updated
2025/07/31
TCI Chemical
Product number
C0257
Product name
4-Chlorophenylhydrazine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$95
Updated
2025/07/31
TCI Chemical
Product number
C0257
Product name
4-Chlorophenylhydrazine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$614
Updated
2025/07/31
Usbiological
Product number
267343
Product name
4-Chlorophenylhydrazine HCl
Packaging
100g
Price
$322
Updated
2021/12/16
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4-Chlorophenylhydrazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to pink crystalline powder

Uses

4-Chlorophenylhydrazine hydrochloride is used as a pharmaceutical intermediates.

General Description

4-Chlorophenylhydrazine hydrochloride reacts with 3-acetonyl-5-cyano-1,2,4-thiadiazole to yield 5-cyano-3-(5-chloro-2-methylindol-3-yl)-1,2,4-thiadiazole and 5-cyano-3-[1-(4-chlorophenyl)-3,5-dimethylpyrazol-4-yl]-1,2,4-thiadiazole.

Synthesis

106-39-8

1073-70-7

The general procedure for the synthesis of p-chlorophenylhydrazine hydrochloride from 4-bromochlorobenzene is as follows: 98.25 g of 4-bromochlorobenzene and 3.3 equivalents of 71% hydrazine hydrate were added to a reaction vessel, to which were added 10 wt.% of the phase transfer catalyst PEG400, 3 times the weight of the solvent acrylhydrazine, and 20 wt.% of a catalyst (copper sulfate in the ratio of copper sulfate to cobalt chloride by mass of 3:1). The reaction process consisted of slowly increasing the temperature to 152 °C, refluxing or packing pressure reaction at atmospheric pressure, and maintaining the reaction at this temperature for 10 hours. During this time, the reaction process was monitored by HPLC and stopped when the amount of p-chlorophenylhydrazone no longer increased. After completion of the reaction, the solid was separated by filtration and the filtrate was distilled to remove the solvent. To the obtained residue, 30% hydrochloric acid was added, the pH was adjusted to 3, and the residue was filtered with thorough stirring. The filtrate was washed with water and dried at 55°C to finally obtain p-chlorophenylhydrazine hydrochloride. In this embodiment, the yield of p-chlorophenylhydrazine hydrochloride was 88.1% and the HPLC purity was 99.29%.

References

[1] Patent: CN105968048, 2016, A. Location in patent: Paragraph 0030-0054; 0055-0059; 0060-0069
[2] Patent: CN106045876, 2016, A. Location in patent: Paragraph 0055; 0056; 0057; 0058; 0059
[3] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[4] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048

4-Chlorophenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 5-chloro-2-indolecarboxylate 5-Chloroindole-2-carboxylic acid 5-CHLORO-1H-INDOLE-2-CARBALDEHYDE 1-(4-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
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4-Chlorophenylhydrazine hydrochloride Suppliers

Americas 1 Austria 1 Belgium 2 China 450 Europe 3 France 1 Germany 6 India 68 Japan 6 Slovakia 1 South Korea 1 Switzerland 5 Ukraine 3 United Kingdom 17 United States 54 Global 619
BTC pharm India
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View Lastest Price from 4-Chlorophenylhydrazine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Chlorophenylhydrazine Hydrochloride 1073-70-7
Price
US $70.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Henan Aochuang Chemical Co.,Ltd.
Product
4-Chlorophenylhydrazine hydrochloride 1073-70-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2025-04-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Chlorophenylhydrazine hydrochloride 1073-70-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-06

1073-70-7, 4-Chlorophenylhydrazine hydrochlorideRelated Search:

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