ChemicalBook > CAS DataBase List > Fleroxacin

Fleroxacin

Product Name
Fleroxacin
CAS No.
79660-72-3
Chemical Name
Fleroxacin
Synonyms
AM-833;QUINODIS;MEGALONE;MEGALOCIN;RO-23-6240;FLEROXACIN;ro23-6240/000;Fleroxacin>Erlotinib-d12 HCl;Fleroxacin, >=99%
CBNumber
CB1331989
Molecular Formula
C17H18F3N3O3
Formula Weight
369.34
MOL File
79660-72-3.mol
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Fleroxacin Property

Melting point:
264-266°C
Boiling point:
535.3±50.0 °C(Predicted)
Density 
1.409±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
0.1 M NaOH: soluble10mg/mL
form 
solid
pka
-0.54±0.20(Predicted)
color 
white to off-white
Merck 
14,4099
CAS DataBase Reference
79660-72-3(CAS DataBase Reference)
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Safety

WGK Germany 
2
RTECS 
VB1999050
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F6807
Product name
Fleroxacin
Purity
≥98% (HPLC)
Packaging
1g
Price
$631
Updated
2023/06/20
Sigma-Aldrich
Product number
33930
Product name
Fleroxacin
Purity
VETRANAL?, analytical standard
Packaging
100MG
Price
$122
Updated
2022/05/15
TCI Chemical
Product number
F0646
Product name
Fleroxacin
Purity
>98.0%(T)
Packaging
5g
Price
$147
Updated
2024/03/01
TCI Chemical
Product number
F0646
Product name
Fleroxacin
Purity
>98.0%(T)
Packaging
25g
Price
$574
Updated
2024/03/01
Cayman Chemical
Product number
24173
Product name
Fleroxacin
Purity
≥98%
Packaging
1g
Price
$57
Updated
2024/03/01
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Fleroxacin Chemical Properties,Usage,Production

Description

Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.

Chemical Properties

White Needle-Like Crystals

Originator

Kyorin (Japan)

Uses

An antibacterial.

Uses

antibiotic

Definition

ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.

Manufacturing Process

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3- carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent evaporated and cooled, the residue was adjusted to pH 1 with aqueous hydrochloric acid. The cooled mixture was filtered off and the solid recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7- (4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08 g), melting point 269-271°C (decomp.).

brand name

Quinodis

Therapeutic Function

Antibacterial

Fleroxacin Preparation Products And Raw materials

Raw materials

Fluorobromoethane 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester QUINOLINE-3-CARBOXYLIC ACID Ethanol 2,3,4-Trifluorobenzenamine Acetic anhydride Diethyl ethoxymethylenemalonate Potassium carbonate

Preparation Products

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Fleroxacin Suppliers

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View Lastest Price from Fleroxacin manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Fleroxacin 79660-72-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Fleroxacin 79660-72-3
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
Fleroxacin 79660-72-3
Price
US $36.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

79660-72-3, FleroxacinRelated Search:

(2-Methoxyethyl)benzene 1-Methylpiperazine DL-α-Tocopherol N-Aminoethylpiperazine Diphenolic acid 4-(Diethylamino)salicylaldehyde 5-Chlorovaleric acid Pralmorelin Methyl 2-hydroxyethyl cellulose Dihydromyrcenol 2-Butanone 4-AMINO-3,5-DIFLUOROACETOPHENONE 3-(4-Methylpiperazin-1-yl)aniline Pefloxacin FLEROXACINLACTATE Norfloxacin 8-FLUORO-4(1H)-QUINOLINONE Benzenamine, 3-(1-piperazinyl)- (9CI)

  • Erlotinib-d12 HCl
  • 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • AM-833, Ro-23-6240, Megalocin, Megalone, Quinodis, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid
  • AM-833, Megalocin, Megalone, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid, 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)quinoline-3-carboxylic acid
  • 6,8-difluoro-1-(2-fluoroethyl)-4-keto-7-(4-methylpiperazin-1-yl)quinoline-3-carboxylic acid
  • 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
  • 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
  • 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid
  • 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Megalone
  • Fleroxacin Solution, 100ppm
  • RO-23-6240
  • QUINODIS
  • 3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-(2-fluoroethyl)-7-(4-met
  • hyl-1-piperazinyl)-4-oxo-
  • ro23-6240/000
  • Fleroxacin solution,1000ppm
  • Fleroxacin, >=99%
  • FLEROXACIN
  • MEGALOCIN
  • MEGALONE
  • AM-833
  • 6,8-DIFLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID
  • 6,8-DIFLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID
  • Fleroxacin&gt
  • Fleroxacin Fleroxacin
  • Fleroxacin, 98%, for analysis
  • 3-Quinolinecarboxylic acid, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
  • Fleroxacin USP/EP/BP
  • 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-4-ium-1-yl)-4-oxoquinoline-3-carboxylate
  • 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • Fluorine Rosa star
  • 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
  • C13658000 Fleroxacin
  • Fleroxacin in Methanol
  • 79660-72-3
  • 79960-72-3
  • 79660-72-7
  • C17H18F3NC3H6O3
  • C17H18F3N3O3
  • Quinodis, Megalocin
  • Antibiotics for Research and Experimental Use
  • Biochemistry
  • Quinolones (Antibiotics for Research and Experimental Use)
  • Intermediates & Fine Chemicals
  • Pharmaceuticals