ChemicalBook > CAS DataBase List > 2-Amino-3-fluoropyridine

2-Amino-3-fluoropyridine

Product Name
2-Amino-3-fluoropyridine
CAS No.
21717-95-3
Chemical Name
2-Amino-3-fluoropyridine
Synonyms
3-FLUOROPYRIDIN-2-AMINE;3-Fluoro-2-aminopyridine;2-Amino-3-fL;BENZYL TERT-BUTANONE;2-AMINO-3-FLUOROPYRIDINE;2-AMIN0-3-FLU0R0PYRIDINE;2-Pyridinamine, 3-fluoro-;3-FLUORO-PYRIDIN-2-YLAMINE;2-Amino-3-fluoropyridine97%;2-AMINO-3-FLUOROPYRIDINE98%
CBNumber
CB1342217
Molecular Formula
C5H5FN2
Formula Weight
112.11
MOL File
21717-95-3.mol
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2-Amino-3-fluoropyridine Property

Melting point:
41-45 °C
Boiling point:
110°C/65mmHg(lit.)
Density 
1.257±0.06 g/cm3(Predicted)
Flash point:
90℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.95±0.36(Predicted)
form 
powder to crystal
color 
White to Gray to Brown
InChI
InChI=1S/C5H5FN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)
InChIKey
WWEINXQNCAWBPD-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC=C1F
CAS DataBase Reference
21717-95-3
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
36/37/38-36-22
Safety Statements 
26-36/37/39
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
707341
Product name
2-Amino-3-fluoropyridine
Purity
97%
Packaging
1g
Price
$66.2
Updated
2025/07/31
TCI Chemical
Product number
A2799
Product name
2-Amino-3-fluoropyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$48
Updated
2025/07/31
TRC
Product number
A898188
Product name
2-Amino-3-fluoropyridine
Packaging
500mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
026754
Product name
2-Amino-3-fluoropyridine
Purity
97%
Packaging
1g
Price
$14
Updated
2021/12/16
AK Scientific
Product number
J94735
Product name
2-Amino-3-fluoropyridine
Packaging
1g
Price
$18
Updated
2021/12/16
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2-Amino-3-fluoropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-3-fluoropyridine is a reagent used in the synthesis of potent sigma-1 receptor antagonists and mu opioid receptor agonists for the treatment of neuropathic pain.

Synthesis

246847-98-3

21717-95-3

General procedure for the synthesis of 2-amino-3-fluoro-5-chloropyridine from 2-amino-3-fluoro-5-chloropyridine: 2-amino-3-fluoro-5-chloropyridine (50 g, 0.341 mol) and methanol (600 mL) were added to a 1000 mL single-necked round-bottomed flask, and stirred until completely dissolved. Ammonia (50 mL) and Pd/C catalyst (2.5 g, 23.5 mmol) were then added. The catalytic hydrogenation reaction was carried out under hydrogen atmosphere until the reaction was complete. After completion of the reaction, the Pd/C catalyst was removed by filtration and the filter cake was washed with methanol. The filtrate and washings were combined and concentrated under reduced pressure to give a white solid crude. The crude was dissolved in water (200 mL x 4) and extracted with ethyl acetate. The organic layer was collected, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the concentrate was pulped with a small amount of petroleum ether and filtered to give 34.50 g of white crystal product in 90.20% yield.

References

[1] Patent: CN105669539, 2016, A. Location in patent: Paragraph 0061; 0062; 0063

2-Amino-3-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-fluoropyridine Suppliers

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View Lastest Price from 2-Amino-3-fluoropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-3-fluoropyridine 21717-95-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-3-fluoropyridine 21717-95-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-3-fluoropyridine 21717-95-3
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

21717-95-3, 2-Amino-3-fluoropyridineRelated Search:

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  • 2-Amino-3-fluoropyridine, CAS 21717-95-3
  • 21717-95-3
  • Pyridine series
  • Fluorine series
  • Amines
  • Pyridines
  • Pyridine