2-Amino-3-fluoropyridine
- Product Name
- 2-Amino-3-fluoropyridine
- CAS No.
- 21717-95-3
- Chemical Name
- 2-Amino-3-fluoropyridine
- Synonyms
- 3-FLUOROPYRIDIN-2-AMINE;3-Fluoro-2-aminopyridine;2-Amino-3-fL;BENZYL TERT-BUTANONE;2-AMINO-3-FLUOROPYRIDINE;2-AMIN0-3-FLU0R0PYRIDINE;2-Pyridinamine, 3-fluoro-;3-FLUORO-PYRIDIN-2-YLAMINE;2-Amino-3-fluoropyridine97%;2-AMINO-3-FLUOROPYRIDINE98%
- CBNumber
- CB1342217
- Molecular Formula
- C5H5FN2
- Formula Weight
- 112.11
- MOL File
- 21717-95-3.mol
2-Amino-3-fluoropyridine Property
- Melting point:
- 41-45 °C
- Boiling point:
- 110°C/65mmHg(lit.)
- Density
- 1.257±0.06 g/cm3(Predicted)
- Flash point:
- 90℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 3.95±0.36(Predicted)
- form
- powder to crystal
- color
- White to Gray to Brown
- InChI
- InChI=1S/C5H5FN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)
- InChIKey
- WWEINXQNCAWBPD-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC=C1F
- CAS DataBase Reference
- 21717-95-3
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HazardClass
- 6.1
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 707341
- Product name
- 2-Amino-3-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $66.2
- Updated
- 2025/07/31
- Product number
- A2799
- Product name
- 2-Amino-3-fluoropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- A898188
- Product name
- 2-Amino-3-fluoropyridine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- V1126
- Product name
- 2-Amino-3-fluoropyridine
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J94735
- Product name
- 2-Amino-3-fluoropyridine
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
2-Amino-3-fluoropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Amino-3-fluoropyridine is a reagent used in the synthesis of potent sigma-1 receptor antagonists and mu opioid receptor agonists for the treatment of neuropathic pain.
Synthesis
246847-98-3
21717-95-3
General procedure for the synthesis of 2-amino-3-fluoro-5-chloropyridine from 2-amino-3-fluoro-5-chloropyridine: 2-amino-3-fluoro-5-chloropyridine (50 g, 0.341 mol) and methanol (600 mL) were added to a 1000 mL single-necked round-bottomed flask, and stirred until completely dissolved. Ammonia (50 mL) and Pd/C catalyst (2.5 g, 23.5 mmol) were then added. The catalytic hydrogenation reaction was carried out under hydrogen atmosphere until the reaction was complete. After completion of the reaction, the Pd/C catalyst was removed by filtration and the filter cake was washed with methanol. The filtrate and washings were combined and concentrated under reduced pressure to give a white solid crude. The crude was dissolved in water (200 mL x 4) and extracted with ethyl acetate. The organic layer was collected, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the concentrate was pulped with a small amount of petroleum ether and filtered to give 34.50 g of white crystal product in 90.20% yield.
References
[1] Patent: CN105669539, 2016, A. Location in patent: Paragraph 0061; 0062; 0063
2-Amino-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-3-fluoropyridine manufacturers
- Product
- 2-Amino-3-fluoropyridine 21717-95-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 2-Amino-3-fluoropyridine 21717-95-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Amino-3-fluoropyridine 21717-95-3
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24