ChemicalBook > CAS DataBase List > Cholesteryl acetate

Cholesteryl acetate

Product Name
Cholesteryl acetate
CAS No.
604-35-3
Chemical Name
Cholesteryl acetate
Synonyms
Chol;ACETYL CHOLESTEROL;CHOLESTERYL ACETATE;CHOLESTEROL ACETATE;Chloesteryl acetate;Cholesterin acetate;Cholesterol 3-Acetate;Cholesterol 3β-Acetate;Perampanel Impurity 40;3β-acetoxy-5-cholestene
CBNumber
CB1346745
Molecular Formula
C29H48O2
Formula Weight
428.69
MOL File
604-35-3.mol
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Cholesteryl acetate Property

Melting point:
112-114 °C (lit.)
alpha 
-44 º (c=2, CHCl3)
Boiling point:
483.49°C (rough estimate)
Density 
0.9935 (rough estimate)
refractive index 
1.5045 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
insoluble
form 
Solid
color 
White to Off-White
optical activity
[α]24/D 44°, c = 2 in chloroform
Water Solubility 
insoluble
Merck 
14,2201
BRN 
2064235
Stability:
Hygroscopic
LogP
10.542 (est)
CAS DataBase Reference
604-35-3(CAS DataBase Reference)
NIST Chemistry Reference
Cholesteryl acetate(604-35-3)
EPA Substance Registry System
Cholest-5-en-3-ol (3.beta.)-, acetate (604-35-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
TSCA 
Yes
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
151114
Product name
Cholesteryl acetate
Purity
97%
Packaging
25g
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
151114
Product name
Cholesteryl acetate
Purity
97%
Packaging
100g
Price
$328
Updated
2024/03/01
Alfa Aesar
Product number
A15052
Product name
Cholesteryl acetate, 97+%
Packaging
25g
Price
$56
Updated
2023/06/20
Alfa Aesar
Product number
A15052
Product name
Cholesteryl acetate, 97+%
Packaging
100g
Price
$109
Updated
2023/06/20
Alfa Aesar
Product number
A15052
Product name
Cholesteryl acetate, 97+%
Packaging
500g
Price
$458
Updated
2023/06/20
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Cholesteryl acetate Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder or needles

Uses

Cholesteryl acetate is used in cosmetics, wrist watches, thermometers, propane tank volume indicators, video displays, pharmaceuticals.

Uses

Cholesteryl acetate is derived from cholesterol, which is a major component of all biological membranes. Approximately 25% of total brain lipid is made up of cholesterol, which is the principal sterol of higher animals. Cholesterol is found in all body tissues, with particularly high concentrations in the brain, spinal cord, and animal fats or oils. Additionally, cholesterol is the main constituent of gallstones.

Preparation

Cholesteryl acetate can be synthesized by the reaction of cholesterol with acetic anhydride in the presence of a catalyst such as pyridine or sulfuric acid. The reaction proceeds as follows:
Cholesterol + Acetic anhydride → Cholesteryl acetate + Acetic acid
The reaction is typically carried out at room temperature or slightly elevated temperatures for several hours. The resulting cholesteryl acetate can be purified by recrystallization from a suitable solvent such as ethanol or acetone.

Definition

ChEBI: Cholesteryl acetate is a cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid. It has a role as a human metabolite. It is a cholesteryl ester and an acetate ester.

Reactions

Monophthalic acid epoxidation of cholesteryl acetate:
A solution of 10 g (0.023 mole) of cholesteryl acetate (mp 112-114°) in ether (50 ml) is mixed with a solution containing 8.4 g (0.046 mole) of monophthalic acid (Chap. 17, Sec. II) in 250 ml of ether. The solution is kept at reflux for 6 hours and then the solvent is removed by distillation (steam bath). The residue is dried under vacuum and digested with 250 ml of dry chloroform. The mixture was filtered to give 6.7 g of phthalic acid (87% recovery). The solvent in the filtrate was evaporated under reduced pressure and the residue was crystallised from 30 ml of methanol to give 6.0 g (58% yield) of β-oxocholesterol acetate. Recrystallisation gives the pure product, melting point 111-112°. Concentration of the filtrate gives 1.55 g (15 per cent yield) of α-oxocholesterol acetate with a melting point of 101-103° after crystallisation from ethanol.

Purification Methods

Crystallise the acetate from n-pentanol or Me2CO. Also purify it by chromatography through silica gel and eluting with MeOH. [Beilstein 6 III 2607, 6 IV 4004.]

Cholesteryl acetate Preparation Products And Raw materials

Raw materials

Acetic anhydride Ammonium chloride Ethyl acetate Cholesterol Sodium bicarbonate Cobalt chloride Magnesium sulfate PETROLEUM ETHER

Preparation Products

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Cholesteryl acetate Suppliers

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View Lastest Price from Cholesteryl acetate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Cholesteryl acetate 604-35-3
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-12-05
Changsha YuTeng New Materials Co., Ltd.
Product
Plant-origin Cholesterol Acetate 604-35-3
Price
US $0.00/g
Min. Order
500g
Purity
99%
Supply Ability
10 kg
Release date
2024-08-30
Zhengzhou Anbu Chem Co.,Ltd
Product
Cholesteryl acetate 604-35-3
Price
US $0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
1000KGS
Release date
2023-06-13

604-35-3, Cholesteryl acetateRelated Search:

POLY(VINYL ACETATE) Sodium acetate Amyl acetate 1-Methoxy-2-propyl acetate Cholesterol Triacetin Glatiramer acetate Benzyl acetate Ethylene glycol monoethyl ether acetate Pralmorelin 5-Chlorovaleric acid Vinyl acetate [(3S,8S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2,4-dichlorobenzoate Ammonium acetate Trenbolone acetate Tocopheryl acetate Diphenolic acid 4-(Diethylamino)salicylaldehyde

  • 3-BETA-HYDROXY-5-CHOLESTENE 3-ACETATE
  • 3BETA-ACETOXY-5-CHOLESTENE
  • CHOLESTEROL ACETATE
  • CHOLESTERYL ACETATE
  • (3beta)-Cholest-5-en-3-ol acetate
  • 5-CHOLESTEN-3BETA-OL 3-ACETATE
  • 5-CHOLESTEN-3-BETA-OL ACETATE
  • 5-CHOLESTEN-3B-OL 3-ACETATE
  • ACETYL CHOLESTEROL
  • ACETIC ACID CHOLESTEROL ESTER
  • ACETIC ACID (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-DIMETHYL-HEXYL)-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL ESTER
  • (3β)-cholest-5-en-3-ylethanoate
  • 3beta-Acetoxycholest-5-ene
  • 3β-acetoxy-5-cholestene
  • 5-Cholesten-3B-ol, acetate
  • Cholest-5-en-3beta-ol acetate
  • Cholest-5-en-3beta-yl acetate
  • Cholest-5-en-3-ol (3beta)-, acetate
  • Cholest-5-en-3-ol(3.beta.)-,acetate
  • CHOLESTERYL ACETATE extrapure
  • 3β-Acetoxy-5-cholestene, 3β-Hydroxy-5-cholestene 3-acetate, 5-Cholesten-3β-ol 3-acetate
  • (3β)-3-Cholesteryl=acetate
  • 3β-Acetoxy-5(6)-cholestene
  • Acetic acid cholest-5-en-3β-yl ester
  • Cholesteryl acetate,3β-Acetoxy-5-cholestene, 3β-Hydroxy-5-cholestene 3-acetate, 5-Cholesten-3β-ol 3-acetate
  • Cholesterol Acetate (C2)
  • (3β)-Cholest-5-en-3-ol Acetate
  • Chol
  • Cholesterol 3-Acetate
  • Cholesterol 3β-Acetate
  • Acetic Acid Cholesterol Ester Acetyl Cholesterol
  • 3b-Acetoxycholest-5-ene
  • Acetic acid cholesteryl ester
  • Chloesteryl acetate
  • CHOLESTERYL ACETATE(REAGENT / STANDARD GRADE)
  • Cholesteryl acetate, 97+%
  • 3-(-)-Cholesteryl acetate
  • 3β-Acetoxycholest-5-ene
  • Cholest-5-en-3β-ol acetate
  • CHOLESTERYL ACETATE (CHOLESTEROL ACETATE)
  • cholest-5-en-3-ol(3β)-,acetate
  • Cholest-5-en-3-yl acetate
  • Cholesterin acetate
  • 3β-Hydroxy-5-cholestene 3-acetate
  • 5-Cholesten-3β-ol 3-acetate
  • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
  • CHOLESTERYL ACETATE(RG)
  • 5-Cholesten-3beta-Ol 3-Acetat
  • CHOLESTERYL ACETATE 97%
  • Cholesterol Acetate &gt
  • Cholest-5-en-3-ol (3β)-, 3-acetate
  • 9a,11a-dimethyl-1-(6-methylheptan-2-yl)-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate
  • [(10R,13R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
  • (-)-Cholesteryl acetate
  • (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
  • Plant-origin Cholesterol Acetate
  • Perampanel Impurity 40
  • 5-CHOLESTEN-3β-OL ACETATE