ChemicalBook > CAS DataBase List > 2,2,2-Trichloroethyl chloroformate
2,2,2-Trichloroethyl chloroformate
- Product Name
- 2,2,2-Trichloroethyl chloroformate
- CAS No.
- 17341-93-4
- Chemical Name
- 2,2,2-Trichloroethyl chloroformate
- Synonyms
- Troc-Cl;2,2,2-trichloroethyl carbonochloridate;Trichloroethyl chloroformate;2,2,2-Trichloroethyl;trichloroethoxycarbonyl chloride;trichloroethylchloroformate;(Trichloroethoxy)chloroformate;2,2,2-TRICHLOROETHYL CHLOROFORMATE;2,2,2 TRI CHLOROETHYL CHLOROFORMAT;2,2,2-trichloroethyl chlorocarbonate
- CBNumber
- CB1372973
- Molecular Formula
- C3H2Cl4O2
- Formula Weight
- 211.86
- MOL File
- 17341-93-4.mol
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2,2,2-Trichloroethyl chloroformate Property
- Melting point:
- 1°C
- Boiling point:
- 171-172 °C (lit.)
- Density
- 1.539 g/mL at 25 °C (lit.)
- vapor pressure
- 0.06 psi ( 20 °C)
- refractive index
- n20/D 1.471(lit.)
- Flash point:
- >100°C
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform, Ethyl Acetate
- form
- Liquid
- color
- Clear light yellow
- Water Solubility
- Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
- Sensitive
- Moisture Sensitive
- BRN
- 970619
- InChIKey
- LJCZNYWLQZZIOS-UHFFFAOYSA-N
- CAS DataBase Reference
- 17341-93-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4)
- EPA Substance Registry System
- Carbonochloridic acid, 2,2,2-trichloroethyl ester (17341-93-4)
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Safety
- Hazard Codes
- T
- Risk Statements
- 23-34-36
- Safety Statements
- 26-36/37/39-45-7/9
- RIDADR
- UN 3277 6.1/PG 2
- WGK Germany
- 3
- F
- 10-19
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29159000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H331Toxic if inhaled
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 142077
- Product name
- 2,2,2-Trichloroethyl chloroformate
- Purity
- 98%
- Packaging
- 25g
- Price
- $69.4
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 142077
- Product name
- 2,2,2-Trichloroethyl chloroformate
- Purity
- 98%
- Packaging
- 100g
- Price
- $186
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0795
- Product name
- 2,2,2-Trichloroethyl Chloroformate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $134
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0795
- Product name
- 2,2,2-Trichloroethyl Chloroformate
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $840
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L06875
- Product name
- 2,2,2-Trichloroethyl chloroformate, 97%
- Packaging
- 25g
- Price
- $50.6
- Updated
- 2024/03/01
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2,2,2-Trichloroethyl chloroformate Chemical Properties,Usage,Production
Chemical Properties
Clear light yellow liquid
Uses
2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
Uses
2,2,2-Trichloroethyl chloroformate was used as:
- derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
- starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
- reagent during N-demethylation of dextromethorphan
- protecting group reagent for amines and alcohols
Application
2,2,2-Trichloroethyl chloroformate is a protecting agent for various functional groups; a net carboxylating agent for organometallic reagents; achieves N-demethylation and N-debenzylation of tertiary amines; and activates N-heteroaromatic rings for reaction with organostannanes.
Preparation
2,2,2-Trichloroethyl chloroformate is widely available commercially. It can be readily prepared by passing Phosgene into a solution of 2,2,2- Trichloroethanol in benzene/diethylaniline or benzene/ether/pyridine. An alternate two-step approach (93% yield) has been described that employs S-Ethyl Chlorothioformate instead of phosgene.
2,2,2-Trichloroethyl chloroformate Preparation Products And Raw materials
Raw materials
Triphosgene
tert-Butyl methyl ether
Toluene
PHOSGENE
Ethyl acetate
Trichloroethanol
Dichloromethane
Pyridine
Magnesium sulfate heptahydrate
Preparation Products
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2,2,2-Trichloroethyl chloroformate Suppliers
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
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View Lastest Price from 2,2,2-Trichloroethyl chloroformate manufacturers
Hebei Weibang Biotechnology Co., Ltd
- Product
- 2,2,2-Trichloroethyl chloroformate 17341-93-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19
Henan Fengda Chemical Co., Ltd
- Product
- 2,2,2-Trichloroethyl chloroformate 17341-93-4
- Price
- US $8.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-23
Hebei Mujin Biotechnology Co.,Ltd
- Product
- 2,2,2-Trichloroethyl chloroformate 17341-93-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-08-24
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