ChemicalBook > CAS DataBase List > 2,2,2-Trichloroethyl chloroformate

2,2,2-Trichloroethyl chloroformate

Product Name
2,2,2-Trichloroethyl chloroformate
CAS No.
17341-93-4
Chemical Name
2,2,2-Trichloroethyl chloroformate
Synonyms
Troc-Cl;2,2,2-trichloroethyl carbonochloridate;Trichloroethyl chloroformate;2,2,2-Trichloroethyl;trichloroethoxycarbonyl chloride;trichloroethylchloroformate;(Trichloroethoxy)chloroformate;2,2,2-TRICHLOROETHYL CHLOROFORMATE;2,2,2 TRI CHLOROETHYL CHLOROFORMAT;2,2,2-trichloroethyl chlorocarbonate
CBNumber
CB1372973
Molecular Formula
C3H2Cl4O2
Formula Weight
211.86
MOL File
17341-93-4.mol
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2,2,2-Trichloroethyl chloroformate Property

Melting point:
1°C
Boiling point:
171-172 °C (lit.)
Density 
1.539 g/mL at 25 °C (lit.)
vapor pressure 
0.06 psi ( 20 °C)
refractive index 
n20/D 1.471(lit.)
Flash point:
>100°C
storage temp. 
2-8°C
solubility 
soluble in Chloroform, Ethyl Acetate
form 
Liquid
color 
Clear light yellow
Water Solubility 
Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
Sensitive 
Moisture Sensitive
BRN 
970619
InChIKey
LJCZNYWLQZZIOS-UHFFFAOYSA-N
CAS DataBase Reference
17341-93-4(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4)
EPA Substance Registry System
Carbonochloridic acid, 2,2,2-trichloroethyl ester (17341-93-4)
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Safety

Hazard Codes 
T
Risk Statements 
23-34-36
Safety Statements 
26-36/37/39-45-7/9
RIDADR 
UN 3277 6.1/PG 2
WGK Germany 
3
F 
10-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
142077
Product name
2,2,2-Trichloroethyl chloroformate
Purity
98%
Packaging
25g
Price
$69.4
Updated
2024/03/01
Sigma-Aldrich
Product number
142077
Product name
2,2,2-Trichloroethyl chloroformate
Purity
98%
Packaging
100g
Price
$186
Updated
2024/03/01
TCI Chemical
Product number
C0795
Product name
2,2,2-Trichloroethyl Chloroformate
Purity
>98.0%(GC)
Packaging
25g
Price
$134
Updated
2024/03/01
TCI Chemical
Product number
C0795
Product name
2,2,2-Trichloroethyl Chloroformate
Purity
>98.0%(GC)
Packaging
250g
Price
$840
Updated
2024/03/01
Alfa Aesar
Product number
L06875
Product name
2,2,2-Trichloroethyl chloroformate, 97%
Packaging
25g
Price
$50.6
Updated
2024/03/01
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2,2,2-Trichloroethyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow liquid

Uses

2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.

Uses

2,2,2-Trichloroethyl chloroformate was used as:

  • derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
  • starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
  • reagent during N-demethylation of dextromethorphan
  • protecting group reagent for amines and alcohols

Application

2,2,2-Trichloroethyl chloroformate is a protecting agent for various functional groups; a net carboxylating agent for organometallic reagents; achieves N-demethylation and N-debenzylation of tertiary amines; and activates N-heteroaromatic rings for reaction with organostannanes.

Preparation

2,2,2-Trichloroethyl chloroformate is widely available commercially. It can be readily prepared by passing Phosgene into a solution of 2,2,2- Trichloroethanol in benzene/diethylaniline or benzene/ether/pyridine. An alternate two-step approach (93% yield) has  been described that employs S-Ethyl Chlorothioformate instead of phosgene.

2,2,2-Trichloroethyl chloroformate Preparation Products And Raw materials

Raw materials

Triphosgene tert-Butyl methyl ether Toluene PHOSGENE Ethyl acetate Trichloroethanol Dichloromethane Pyridine Magnesium sulfate heptahydrate

Preparation Products

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View Lastest Price from 2,2,2-Trichloroethyl chloroformate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Henan Fengda Chemical Co., Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $8.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-23
Hebei Mujin Biotechnology Co.,Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-08-24

17341-93-4, 2,2,2-Trichloroethyl chloroformateRelated Search:

Ethyl formate Trichlorosilane 2-Chloroethyl chloroformate Sucralose Urethane 1-Chloroethyl chloroformate Triethyl orthoformate Diethyl azodicarboxylate Tris(2-chloroethyl) phosphate Trichloroethylene Ethyl cyanoformate Ethyl maltol Hydroxyethyl Cellulose Diethyl phthalate Ethyl chloroformate Chloroform 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE 1,1,1-Trichloroethane

  • 2,2,2-trichloroethyl carbonochloridate
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  • 2,2,2-Trichloroethyl chloroformate,96%
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  • Chloroformic Acid 2,2,2-Trichloroethyl Ester,95%
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  • BETA,BETA,BETA-TRICHLOROETHOXYCARBONYL CHLORIDE
  • CHLOROFORMIC ACID 2,2,2-TRICHLOROETHYL ESTER
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  • carbonochloridicacid,2,2,2-trichloroethylester
  • Formic acid, chloro-, 2,2,2-trichloroethyl ester
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  • trichloroethylchloroformate
  • Chloroformic acid 2,2,2-trichloroethyl ester~2,2,2-Trichloroethoxycarbonyl chloride~TrocCl
  • 2,2,2 TRI CHLOROETHYL CHLOROFORMAT
  • 2,2,2-Trichloroethylchloroformate99%
  • 2,2,2-trichloroethylchloranuidylformate
  • Trichloroethoxycarbonyl chloride(Troc-CL)
  • 2,2,2-Trichloroethyl Chloroformate &gt
  • Troc-CL trichloroethoxycarbonyl chloride ,97%
  • 2,2,2-Trichlorethoxycarbonyl chloride
  • 2,2,2-Trichloroethyl chloroformate17341-93-4
  • 2,2,2-TRICHLOROETHYL CHLOROFORMATE Extra Pure
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  • β-D-Fructopyranose,1,2:4,5-bis-O-(1-methylethylidene)-,sulfamate(9CI)
  • 17341-93-4
  • 1734-19-3
  • ClCO2CH2CCl3
  • ClCOOCH2CCl3
  • C3H2Cl4O2
  • Protection & Derivatization Reagents (for Synthesis)
  • Acid Halides
  • Organic Building Blocks
  • Carbonyl Compounds
  • Building Blocks
  • Acid Halides
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Miscellaneous
  • Protection & Derivatization Reagents (for Synthesis)