Trimethylhydroquinone
The intermediate of Vitamin E Chemical Properties Uses Production method- Product Name
- Trimethylhydroquinone
- CAS No.
- 700-13-0
- Chemical Name
- Trimethylhydroquinone
- Synonyms
- 1,4-Benzenediol, 2,3,5-trimethyl-;tmhq;2,3,5-TRIMETHYLHYDROQUINONE;-Cumoquinol;2,3,5- trimethyl-1;psi-Cumohydroquinone;Trimethylhydroqninone;TRIMETHYLHYDROQUINONE;trimethyl-hydroquinon;2,3,5-Trimethylquinol
- CBNumber
- CB1403963
- Molecular Formula
- C9H12O2
- Formula Weight
- 152.19
- MOL File
- 700-13-0.mol
Trimethylhydroquinone Property
- Melting point:
- 169-172 °C (lit.)
- Boiling point:
- 295 °C (759.8513 mmHg)
- Density
- 0.9595 (rough estimate)
- vapor pressure
- 0-0.017Pa at 20-50℃
- refractive index
- 1.4464 (estimate)
- Flash point:
- 191 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- methanol: 0.1 g/mL, clear
- pka
- 11.28±0.28(Predicted)
- form
- Crystalline Powder
- color
- Beige
- Water Solubility
- 2 g/L (20 ºC)
- BRN
- 1909183
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- AUFZRCJENRSRLY-UHFFFAOYSA-N
- LogP
- 3.32 at 25℃
- Dissociation constant
- 10.8-12.9
- CAS DataBase Reference
- 700-13-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Trimethylhydroquinone(700-13-0)
- EPA Substance Registry System
- 1,4-Benzenediol, 2,3,5-trimethyl- (700-13-0)
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 20-37/38-41-43-50/53
- Safety Statements
- 24-26-37/39-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 2
- RTECS
- MX7820000
- F
- 9-23
- TSCA
- Yes
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29072990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T76503
- Product name
- Trimethylhydroquinone
- Purity
- 97%
- Packaging
- 100g
- Price
- $72.7
- Updated
- 2024/03/01
- Product number
- T76503
- Product name
- Trimethylhydroquinone
- Purity
- 97%
- Packaging
- 500g
- Price
- $113
- Updated
- 2024/03/01
- Product number
- T0477
- Product name
- Trimethylhydroquinone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- T0477
- Product name
- Trimethylhydroquinone
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $134
- Updated
- 2024/03/01
- Product number
- B22819
- Product name
- Trimethylhydroquinone
- Purity
- 98%
- Packaging
- 100g
- Price
- $45.65
- Updated
- 2024/03/01
Trimethylhydroquinone Chemical Properties,Usage,Production
The intermediate of Vitamin E
Trimethylhydroquinone and isophytol are two intermediate in the synthesis of vitamin E, currently trimethylhydroquinone in world market is mainly produced by BASF and Roche, it can not meet the needs of vitamin E. The 2,3,5-trimethyl hydroquinone of China is put into operation by only a few companies, China has become the world's second largest feed production country, if the amount of vitamin E in animal feed reach the average level of foreign words, the annual consumption vitamin E is nearly 2000t. According to Chinese feed industry planning, the amount of feed demand synthetic vitamin E is about 2500t in 2005. Furthermore, the needs of vitamin E in pharmaceutical, food, cosmetics and other needs for vitamin E will grow steadily in the future. So in the last ten years, or even 20 years, the future market 2,3,5-trimethyl hydroquinone can not be not saturated. The development of this project has broad application prospects.
Vitamin E is not only used as a medicine, feed, food, cosmetic additives, but also get more and more applications in industry, such as industrial antioxidants, polyolefin non-toxic, biodegradable stabilizer. A sharp increase in domestic and international market demand for vitamin E is present. The naturally occurring vitamin E is very limited, so timely start-up and expansion of production of vitamin E will bring better economic benefits.
The above information is edited by the chemicalbook of Wang Xiaodong.
Chemical Properties
It is crystalline solid. When heated, it can sublimate, when esposed to moisture, it can turn black easily. It can be slightly soluble in water, soluble in ethyl alcohol, insoluble in petroleum ether. Melting point is 173℃.
Uses
The product is main ring of vitamin E, it can condensation with isophytol to get vitamin E.
Organic intermediates, pharmaceutical intermediates, it can be used for the synthesis of VE.
Production method
By sulfonation, nitration, reduction, oxidation 1,2,4-trimethylbenzene can get 2,3,5-trimethyl benzoquionone ([935-92-2]). 2,3,5-trimethyl benzoquionone is yellow needle crystallization, melting point is 32℃ (38-29.5℃), the boiling point is 53℃(53Pa). Said step of products are generally to obtain a solution of petroleum ether or gasoline. In 2,3,5-trimethyl gasoline solution (petroleum ether), hydrosulfite solution is added with stirring, stir at room temperature for 3h, then filter, the cake should be washed with 0.5% hydrosulfite solution, and then dry to get trimethyl hydroquinone.
Chemical Properties
off-white, tan or orange powder
Uses
Trimethylhydroquinone is used for synthesizing vitamin E and used as medical intermediate.
Uses
Trimethylhydroquinone is a key precursor for the synthesis of tocopherols (vitamin E) and (±)-madindolines.
Definition
ChEBI: 2,3,5-trimethylhydroquinone is a member of the class of hydroquinones that is hydroquinone substituted by methyl groups at positions 2, 3 and 5. It is a member of hydroquinones and a methylbenzene.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 16, p. 378, 1968 DOI: 10.1248/cpb.16.378
Safety Profile
Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Recrystallise the hydroquinone from water, under anaerobic conditions. [Beilstein 6 H 931, 6 IV 5997.]
Trimethylhydroquinone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethylhydroquinone manufacturers
- Product
- Trimethylhydroquinone 700-13-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Week
- Release date
- 2024-05-10
- Product
- Trimethylhydroquinone 700-13-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-05-23
- Product
- Trimethylhydroquinone 700-13-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-05